Serum uric acid concentration and metabolic syndrome among elderly Koreans: The Korean Urban Rural Elderly (KURE) study

被引:31
作者
Choi, Hansol [1 ,2 ]
Kim, Hyeon Chang [2 ,3 ]
Song, Bo Mi [1 ,2 ]
Park, Ji Hye [1 ,2 ]
Lee, Ju-Mi [4 ]
Yoon, Da-Lim [5 ]
Yoon, Young Mi [2 ]
Rhee, Yumie [5 ]
Youm, Yousik [6 ]
Kim, Chang Oh [5 ]
机构
[1] Yonsei Univ, Grad Sch, Dept Publ Hlth, Seoul 120749, South Korea
[2] Yonsei Univ, Coll Med, Cardiovasc & Metab Dis Etiol Res Ctr, Seoul, South Korea
[3] Yonsei Univ, Coll Med, Dept Prevent Med, 50-1 Yonsei Ro, Seoul 120752, South Korea
[4] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
[5] Yonsei Univ, Coll Med, Dept Internal Med, 50 Yonsei Ro, Seoul 120752, South Korea
[6] Yonsei Univ, Coll Social Sci, Dept Sociol, Seoul 120749, South Korea
关键词
Uric acid; Metabolic syndrome; Metabolic abnormality; Elderly; C-REACTIVE PROTEIN; HEALTH; METAANALYSIS; ASSOCIATION; PREVALENCE; COMPONENTS;
D O I
10.1016/j.archger.2016.01.005
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: Epidemiologic studies have demonstrated that elevated serum uric acid concentration is an independent risk factor for metabolic syndrome. However, few studies have focused on elderly populations. Thus, we investigated the association of serum uric acid concentration with metabolic syndrome in community-dwelling elderly Koreans. Methods: This cross-sectional analysis included 2940 participants (986 men and 1954 women) aged 65 years or older who participated in a baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2014. Serum uric acid concentration was analyzed using both continuous and dichotomous variables. Hyperuricemia was defined as a uric acid concentration >= 7.0 mg/dL in men and >6.0 mg/dL in women. Metabolic syndrome was defined according to the 2009 harmonizing definition. Multiple logistic regression models were used to investigate independent association between serum uric acid and metabolic syndrome, after adjusting for age, body mass index, LDL cholesterol, glycated hemoglobin, blood urea nitrogen, estimated glomerular filtration rate health behaviors, and medications. Results: Prevalence of metabolic syndrome and its components increased significantly according to uric acid concentration in both sexes. The adjusted odds ratios for having metabolic syndrome per 1.0 mg/dL higher uric acid concentration were 1.16 (95% CI: 1.03-1.31) in men and 1.27 (95% CI: 1.13-1.42) in women. Hyperuricemia was also associated with metabolic syndrome, with adjusted odds ratios of 1.71 (95% CI: 1.11-2.63) in men and 1.55 (95% CI: 1.05-2.29) in women. Conclusions: Elevated serum uric acid concentration was independently associated with an increased prevalence of metabolic syndrome in community-dwelling elderly Koreans. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:51 / 58
页数:8
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