Clopidogrel pathway

被引：193

作者：

Sangkuhl, Katrin

Klein, Teri E. ^{[1
]}

Altman, Russ B. ^{[2
]}

机构：

[1] Stanford Univ, Med Ctr, Dept Genet, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

来源：

PHARMACOGENETICS AND GENOMICS | 2010年 / 20卷 / 07期

关键词：

clopidogrel; CYP2C19; CYP2C19*2; 2-oxo-clopidogrel; PharmGKB; pharmacokinetics; platelet aggregation; thienopyridine; OF-FUNCTION POLYMORPHISM; ACUTE CORONARY SYNDROME; PROTON PUMP INHIBITORS; DRUG-DRUG INTERACTION; CYTOCHROME-P450; 3A; ATORVASTATIN; RESPONSIVENESS; PHARMACOKINETICS; ASSOCIATION; METABOLISM;

D O I：

10.1097/FPC.0b013e3283385420

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

收藏

页码：463 / 465

页数：3

相关论文

共 30 条

[11]

Herbert Jean-Marc, 2003, Semin Vasc Med, V3, P113

[12] Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Coronary Syndrome [J].

Ho, P. Michael ;

Maddox, Thomas M. ;

Wang, Li ;

Fihn, Stephan D. ;

Jesse, Robert L. ;

Peterson, Eric D. ;

Rumsfeld, John S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 301 (09) :937-944

[13] Cytochrorne P4502C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects [J].

Hulot, Jean-Sebastien ;

Bura, Alessandra ;

Villard, Eric ;

Azizi, Michel ;

Remones, Veronique ;

Goyenvalle, Catherine ;

Aiach, Martine ;

Lechat, Philippe ;

Gaussem, Pascale .

BLOOD, 2006, 108 (07) :2244-2247

[14] Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite [J].

Kazui, Miho ;

Nishiya, Yumi ;

Ishizuka, Tomoko ;

Hagihara, Katsunobu ;

Farid, Nagy A. ;

Okazaki, Osamu ;

Ikeda, Toshihiko ;

Kurihara, Atsushi .

DRUG METABOLISM AND DISPOSITION, 2010, 38 (01) :92-99

[15] Clopidogrel and Calcium-Channel Antagonists Another Drug-Drug Interaction for the Ever-Wary Clinician? [J].

Kleiman, Neal S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (19) :1564-1566

[16]

Kurihara A., 2005, DRUG METAB REV S2, V37, P99

[17] Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation - A new drug-drug interaction [J].

Lau, WC ;

Waskell, LA ;

Watkins, PB ;

Neer, CJ ;

Horowitz, K ;

Hopp, AS ;

Tait, AR ;

Carville, DGM ;

Guyer, KE ;

Bates, ER .

CIRCULATION, 2003, 107 (01) :32-37

[18]

Levin L S, 1981, J Md State Dent Assoc, V24, P21

[19]

Lins R, 1999, SEMIN THROMB HEMOST, V25, P29

[20] High-dose atorvastatin does not negatively influence clinical outcomes among clopidogrel treated acute coronary syndrome patients - A Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) analysis [J].

Lotfi, Amir ;

Schweiger, Marc J. ;

Giugliano, Gregory R. ;

Murphy, Sabina A. ;

Cannon, Christopher P. .

AMERICAN HEART JOURNAL, 2008, 155 (05) :954-958