Minimizing off-target effects in CRISPR-Cas9 genome editing

被引:28
作者
Chen, Shi-Jie [1 ,2 ]
机构
[1] Univ Missouri, Dept Biochem, Dept Phys, Columbia, MO 65211 USA
[2] Univ Missouri, UM Inst Informat, Columbia, MO 65211 USA
关键词
NUCLEASES; CAS9; SPECIFICITY;
D O I
10.1007/s10565-019-09486-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:399 / 401
页数:3
相关论文
共 12 条
[11]   CRISPR-Cas9 cleavage efficiency correlates strongly with target-sgRNA folding stability: from physical mechanism to off-target assessment [J].
Xu, Xiaojun ;
Duan, Dongsheng ;
Chen, Shi-Jie .
SCIENTIFIC REPORTS, 2017, 7
[12]   Unified energetics analysis unravels SpCas9 cleavage activity for optimal gRNA design [J].
Zhang, Dong ;
Hurst, Travis ;
Duan, Dongsheng ;
Chen, Shi-Jie .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (18) :8693-8698