The Remarkably High Prevalence of Epilepsy and Seizure History in Fetal Alcohol Spectrum Disorders

被引:69
作者
Bell, Stephanie H. [1 ]
Stade, Brenda [2 ,8 ]
Reynolds, James N. [1 ]
Rasmussen, Carmen [3 ]
Andrew, Gail [3 ]
Hwang, Paul A. [6 ,7 ]
Carlen, Peter L. [4 ,5 ,7 ]
机构
[1] Queens Univ, Dept Pharmacol & Toxicol, Kingston, ON K7L 3N6, Canada
[2] St Michaels Hlth Ctr, Dept Pediat, Toronto, ON, Canada
[3] Univ Alberta, Dept Pediat, Toronto, ON, Canada
[4] Univ Hlth Network, Toronto, ON, Canada
[5] Univ Toronto, Toronto Western Res Inst, Toronto, ON, Canada
[6] N York Gen Hosp, Toronto, ON, Canada
[7] Univ Toronto, Epilepsy Res Ctr, Toronto, ON, Canada
[8] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Appl Hlth Res Ctr, Toronto, ON M5B 1W8, Canada
基金
加拿大健康研究院;
关键词
Fetal Alcohol Spectrum Disorders; Epilepsy; Seizures; RISK-FACTORS; CHILDREN; ROCHESTER; EXPOSURE; LIFE; ADHD;
D O I
10.1111/j.1530-0277.2010.01184.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: Fetal alcohol spectrum disorder (FASD) is the umbrella term that describes the range of adverse developmental outcomes that may occur in the offspring of mothers who drink alcohol during pregnancy. FASD is associated with several comorbidities including epilepsy. The objective of the study was to evaluate the prevalence of epilepsy or a history of seizures in subjects with FASD and the contribution of relevant risk factors. Methods: A retrospective chart review was conducted on all active charts (N = 1063) at two FASD clinics. After exclusion of subjects without a confirmed diagnosis, a total of 425 subjects between the ages of 2-49 were included in the analysis. The relationships between FASD diagnosis and other risk factors for co-occurrence of epilepsy or a seizure disorder (e.g., extent of exposure to alcohol and other drugs, type of birth, and trauma) were examined using chi-square and multivariate multinomial logistic regression. Results: Twenty-five (5.9%) individuals in the study population had a confirmed diagnosis of epilepsy, and 50 (11.8%) had at least one documented seizure episode, yielding an overall prevalence of 17.7% in this population. Importantly, a history of epilepsy or seizures was not different across the three diagnostic subgroups. In those subjects with available maternal drinking histories, first trimester exposure or drinking throughout all three trimesters were the predominant forms of fetal exposure. None of the other risk factors were associated with a greater prevalence of epilepsy or seizures. Conclusions: There is a remarkably high prevalence of epilepsy/seizures in the FASD population.
引用
收藏
页码:1084 / 1089
页数:6
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