The HLA locus and multiple sclerosis in Sicily

被引：27
作者：
Brassat, D
Salemi, G
Barcellos, LF
McNeill, G
Proia, P
Hauser, SL
Oksenberg, JR
Savettieri, G
机构：
[1] Univ Calif San Francisco, Sch Med, Dept Neurol, San Francisco, CA 94143 USA
[2] Univ Palermo, Dept Neurol Ophthalmol Otolaryngol & Psychiat, I-90133 Palermo, Italy
[3] Univ Palermo, Dept Cellular & Dev Biol, I-90133 Palermo, Italy
[4] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Berkeley, CA 94720 USA
来源：
NEUROLOGY | 2005年 / 64卷 / 02期
关键词：
D O I：
10.1212/01.WNL.0000149765.71212.0A
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors report the analysis of HLA-class II allelic heterogeneity in a well characterized multiple sclerosis ( MS) Sicilian dataset. Family-based association analysis revealed evidence for excess transmission to affected individuals for alleles HLA-DRB1*1501, DRB1*04, and DQB1*0302. When analyzed as haplotypes, the authors observed excess transmission for the DRB1*0400-DQB1*0302 haplotype. Sicilian patients share the HLA-DRB1*1501 susceptibility allele with affecteds living in continental Italy, but also display the allelic heterogeneity that characterizes Mediterranean populations.
引用
收藏
页码：361 / 363
页数：3
相关论文
共 10 条
[1]   HLA-multiple sclerosis association in continental Italy and correlation with disease prevalence in Europe [J].
Ballerini, C ;
Guerini, FR ;
Rombolà, G ;
Rosati, E ;
Massacesi, L ;
Ferrante, P ;
Caputo, D ;
Talamanca, LF ;
Naldi, P ;
Liguori, M ;
Alizadeh, M ;
Momigliano-Richiardi, P ;
D'Alfonso, S .
JOURNAL OF NEUROIMMUNOLOGY, 2004, 150 (1-2) :178-185
[2]   Familial factors influence disability in MS multiplex families [J].
Brassat, D ;
Azais-Vuillemin, C ;
Yaouanq, J ;
Semana, G ;
Reboul, J ;
Cournu, I ;
Mertens, C ;
Edan, G ;
Lyon-Caen, O ;
Clanet, C ;
Fontaine, B .
NEUROLOGY, 1999, 52 (08) :1632-1636
[3]   Multiple sclerosis in Malta in 1999: an update [J].
Dean, G ;
Elian, M ;
de Bono, AG ;
Asciak, RP ;
Vella, N ;
Mifsud, V ;
Aquilina, J .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2002, 73 (03) :256-260
[4]   Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity [J].
Haines, JL ;
Terwedow, HA ;
Burgess, K ;
Pericak-Vance, MA ;
Rimmler, JB ;
Martin, ER ;
Oksenberg, JR ;
Lincoln, R ;
Zhang, DY ;
Banatao, DR ;
Gatto, N ;
Goodkin, DE ;
Hauser, SL .
HUMAN MOLECULAR GENETICS, 1998, 7 (08) :1229-1234
[5]   Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia [J].
Marrosu, MG ;
Murru, R ;
Murru, MR ;
Costa, G ;
Zavattari, P ;
Whalen, M ;
Cocco, E ;
Mancosu, C ;
Schirru, L ;
Solla, E ;
Fadda, E ;
Melis, C ;
Porru, I ;
Rolesu, M ;
Cucca, F .
HUMAN MOLECULAR GENETICS, 2001, 10 (25) :2907-2916
[6]   Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans [J].
Oksenberg, JR ;
Barcellos, LF ;
Cree, BAC ;
Baranzini, SE ;
Bugawan, TL ;
Khan, O ;
Lincoln, RR ;
Swerdlin, A ;
Mignot, E ;
Lin, L ;
Goodin, D ;
Erlich, HA ;
Schmidt, S ;
Thomson, G ;
Reich, DE ;
Pericak-Vance, MA ;
Haines, JL ;
Hauser, SL .
AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 74 (01) :160-167
[7]   NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS [J].
POSER, CM ;
PATY, DW ;
SCHEINBERG, L ;
MCDONALD, WI ;
DAVIS, FA ;
EBERS, GC ;
JOHNSON, KP ;
SIBLEY, WA ;
SILBERBERG, DH ;
TOURTELLOTTE, WW .
ANNALS OF NEUROLOGY, 1983, 13 (03) :227-231
[8]   Epidemiology of multiple sclerosis in Sicily [J].
Savettieri, G ;
Ragonese, P ;
Aridon, P ;
Salemi, G .
NEUROLOGICAL SCIENCES, 2001, 22 (02) :175-177
[9]   The HLA locus and multiple sclerosis in Spain.: Role in disease susceptibility, clinical course and response to interferon-β [J].
Villoslada, P ;
Barcellos, LF ;
Rio, J ;
Begovich, AB ;
Tintore, M ;
Sastre-Garriga, J ;
Baranzini, SE ;
Casquero, P ;
Hauser, SL ;
Montalban, X ;
Oksenberg, JR .
JOURNAL OF NEUROIMMUNOLOGY, 2002, 130 (1-2) :194-201
[10]   Mitochondrial DNA sequence analysis in Sicily [J].
Vona, G ;
Ghiani, ME ;
Calò, CM ;
Vacca, L ;
Memmì, M ;
Varesi, L .
AMERICAN JOURNAL OF HUMAN BIOLOGY, 2001, 13 (05) :576-589
1