Prevention of Advanced Cancer by Vitamin D3 Supplementation: Interaction by Body Mass Index Revisited

被引：6
作者：
Brenner, Hermann [1 ,2 ,3 ,4 ,5 ]
Kuznia, Sabine [1 ,6 ]
Laetsch, Clarissa [1 ]
Niedermaier, Tobias [1 ,4 ]
Schoettker, Ben [1 ,5 ]
机构：
[1] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany
[2] German Canc Res Ctr, Div Prevent Oncol, D-69120 Heidelberg, Germany
[3] Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany
[4] German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany
[5] Heidelberg Univ, Network Aging Res NAR, D-69115 Heidelberg, Germany
[6] Heidelberg Univ, Med Fac Heidelberg, D-69120 Heidelberg, Germany
来源：
NUTRIENTS | 2021年 / 13卷 / 05期
关键词：
body mass index; cancer; prevention; supplementation; vitamin D; MEAN SOJOURN TIME; COLORECTAL-CANCER; METAANALYSIS; MORTALITY; SURVIVAL; COHORT;
D O I：
10.3390/nu13051408
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Meta-analyses of randomized controlled trials (RCTs) have demonstrated a protective effect of vitamin D-3 (cholecalciferol) supplementation against cancer mortality. In the VITAL study, a RCT including 25,871 men >= 50 years and women >= 55 years, protective effects of vitamin D-3 supplementation (2000 IU/day over a median of 5.3 years) with respect to incidence of any cancer and of advanced cancer (metastatic cancer or cancer death) were seen for normal-weight participants but not for overweight or obese participants. We aimed to explore potential reasons for this apparent variation of vitamin D effects by body mass index. We conducted complementary analyses of published data from the VITAL study on the association of body weight with cancer outcomes, stratified by vitamin D-3 supplementation. Significantly increased risks of any cancer and of advanced cancer were seen among normal-weight participants compared to obese participants in the control group (relative risk (RR), 1.27; 95% confidence interval (CI), 1.07-1.52, and RR, 1.44; 95% CI, 1.04-1.97, respectively). No such patterns were seen in the intervention group. Among those with incident cancer, vitamin D-3 supplementation was associated with a significantly reduced risk of advanced cancer (RR, 0.86; 95% CI, 0.74-0.99). The observed patterns point to pre-diagnostic weight loss of cancer patients and preventive effects of vitamin D-3 supplementation from cancer progression as plausible explanations for the body mass index (BMI)-intervention interactions. Further research, including RCTs more comprehensively exploring the potential of adjuvant vitamin D therapy for cancer patients, should be pursued with priority.
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页数：7
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