Long-term molecular remission induced by donor lymphocyte infusions for recurrent acute myeloblastic leukemia after allogeneic bone marrow transplantation

被引：7

作者：

Imoto, S ^{[1
]}

Murayama, T ^{[1
]}

Gomyo, H ^{[1
]}

Mizuno, I ^{[1
]}

Sugimoto, T ^{[1
]}

Nakagawa, T ^{[1
]}

Koizumi, T ^{[1
]}

机构：

[1] Hyogo Med Ctr Adults, Dept Internal Med, Div Hematol Oncol, Akashi, Hyogo 6738558, Japan

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 07期

关键词：

acute leukemia; allogeneic bone marrow transplantation; relapse; donor lymphocyte infusion; graft-versus-host disease; graft-versus-leukemia effect;

D O I：

10.1038/sj.bmt.1702602

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A case of acute myelogenous leukemia with a t(8;21) translocation relapsed 5 months after allogeneic bone marrow transplantation (allo-BMT), After chemotherapy-induced hematologic remission, the patient received donor lymphocyte infusions (DLI); 4.9 x 10(8)/kg T cells were infused. After DLI, she achieved molecular CR for the first time after allo-BMT, which lasted for 40 months. However, she suffered from grade III acute GVHD of the skin and the liver. Hepatic GVHD was sustained and resulted in fatal outcome. The case demonstrates that DLI is a double-edged sword. Further study is necessary before DLI can be considered to be a beneficial therapy for acute leukemia.

引用

页码：809 / 810

页数：2

共 50 条

[31] Donor Lymphocyte Infusion for Relapsed Hematological Malignancies after Unrelated Allogeneic Bone Marrow Transplantation Facilitated by the Japan Marrow Donor Program [J].

Miyamoto, Toshihiro ;

Fukuda, Takahiro ;

Nakashima, Marie ;

Henzan, Tomoko ;

Kusakabe, Shinsuke ;

Kobayashi, Naoki ;

Sugita, Junichi ;

Mori, Takeshi ;

Kurokawa, Mineo ;

Mori, Shin-ichiro .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2017, 23 (06) :938-944

[32] Donor leukocyte infusions for the treatment of relapsed acute leukemia after allogeneic stem cell transplantation [J].

Loren, A. W. ;

Porter, D. L. .

BONE MARROW TRANSPLANTATION, 2008, 41 (05) :483-493

[33] Donor leukocyte infusions for the treatment of relapsed acute leukemia after allogeneic stem cell transplantation [J].

A W Loren ;

D L Porter .

Bone Marrow Transplantation, 2008, 41 :483-493

[34] Factors affecting survival in acute leukemia with donor lymphocyte infusion in the first relapse after allogeneic stem cell transplantation [J].

Kurnaz, Fatih ;

Sahin, Cem ;

Kaynar, Leylagul ;

Pala, Cigdem ;

Sivgin, Serdar ;

Altuntas, Fevzi ;

Eser, Bulent ;

Cetin, Mustafa ;

Unal, Ali .

JOURNAL OF BUON, 2016, 21 (01) :227-234

[35] Donor lymphocyte infusion for childhood acute lymphoblastic leukaemia relapsing after bone marrow transplantation [J].

Atra, A ;

Millar, B ;

Shepherd, V ;

Shankar, A ;

Wilson, K ;

Treleaven, J ;

PritchardJones, K ;

Meller, ST ;

Pinkerton, CR .

BRITISH JOURNAL OF HAEMATOLOGY, 1997, 97 (01) :165-168

[36] Partial Reconstitution of Cutaneous Microvessels in Long-Term Survivors after Allogeneic Bone Marrow Transplantation [J].

Haeusermann, P. ;

Kump, E. ;

Rovo, A. ;

Tichelli, A. ;

Itin, P. ;

Gratwohl, A. ;

Biedermann, B. C. .

DERMATOLOGY, 2009, 219 (01) :32-41

[37] Prognostic value of hematopoietic chimerism in patients with acute leukemia after allogeneic bone marrow transplantation: a prospective study [J].

Choi, SJ ;

Lee, KH ;

Lee, JH ;

Kim, S ;

Chung, HJ ;

Lee, JS ;

Kim, SH ;

Park, CJ ;

Chi, HS ;

Kim, WK .

BONE MARROW TRANSPLANTATION, 2000, 26 (03) :327-332

[38] Long-term follow-up of patients undergoing allogeneic bone marrow transplantation for acute myeloid leukemia in first complete remission after cyclophosphamide-total body irradiation and cyclosporine [J].

Mehta, J ;

Powles, R ;

Treleaven, J ;

Horton, C ;

Tait, D ;

Meller, S ;

Pinkerton, CR ;

Middleton, G ;

Eisen, T ;

Singhal, S .

BONE MARROW TRANSPLANTATION, 1996, 18 (04) :741-746

[39] Prognostic value of hematopoietic chimerism in patients with acute leukemia after allogeneic bone marrow transplantation: a prospective study [J].

S-J Choi ;

K-H Lee ;

J-H Lee ;

S Kim ;

H-J Chung ;

J-S Lee ;

S-H Kim ;

C-J Park ;

H-S Chi ;

W-K Kim .

Bone Marrow Transplantation, 2000, 26 :327-332

[40] Pulmonary function changes in long-term survivors of chronic myelogenous leukemia after allogeneic bone marrow transplantation: A Taiwan experience [J].

Chiou, TJ ;

Tung, SL ;

Wang, WS ;

Tzeng, WF ;

Yen, CC ;

Fan, FS ;

Liu, JH ;

Chen, PM .

CANCER INVESTIGATION, 2002, 20 (7-8) :880-888

← 1 2 3 4 5 →