Long-term molecular remission induced by donor lymphocyte infusions for recurrent acute myeloblastic leukemia after allogeneic bone marrow transplantation

被引：7
作者：
Imoto, S [1 ]
Murayama, T [1 ]
Gomyo, H [1 ]
Mizuno, I [1 ]
Sugimoto, T [1 ]
Nakagawa, T [1 ]
Koizumi, T [1 ]
机构：
[1] Hyogo Med Ctr Adults, Dept Internal Med, Div Hematol Oncol, Akashi, Hyogo 6738558, Japan
来源：
BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 07期
关键词：
acute leukemia; allogeneic bone marrow transplantation; relapse; donor lymphocyte infusion; graft-versus-host disease; graft-versus-leukemia effect;
D O I：
10.1038/sj.bmt.1702602
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A case of acute myelogenous leukemia with a t(8;21) translocation relapsed 5 months after allogeneic bone marrow transplantation (allo-BMT), After chemotherapy-induced hematologic remission, the patient received donor lymphocyte infusions (DLI); 4.9 x 10(8)/kg T cells were infused. After DLI, she achieved molecular CR for the first time after allo-BMT, which lasted for 40 months. However, she suffered from grade III acute GVHD of the skin and the liver. Hepatic GVHD was sustained and resulted in fatal outcome. The case demonstrates that DLI is a double-edged sword. Further study is necessary before DLI can be considered to be a beneficial therapy for acute leukemia.
引用
收藏
页码：809 / 810
页数：2
相关论文
共 50 条
  • [11] Does donor–recipient ABO incompatibility protect against relapse after allogeneic bone marrow transplantation in first remission acute myeloid leukemia?
    J Mehta
    R Powles
    B Sirohi
    J Treleaven
    S Kulkarni
    R Saso
    D Tait
    S Singhal
    Bone Marrow Transplantation, 2002, 29 : 853 - 859
  • [12] Donor leukocyte transfusions and discontinuation of immunosuppressants to achieve an initial remission after allogeneic bone marrow transplantation in a patient with primary refractory acute leukemia
    Azuno, Y
    Kaneko, T
    Nishimura, M
    Okuya, S
    Nakai, K
    Nomiyama, J
    Mori, K
    Okafuji, K
    Okubo, M
    Matsutani, A
    Kamei, S
    Zaitsu, Y
    Takeuchi, Y
    Oka, Y
    Kaku, K
    BONE MARROW TRANSPLANTATION, 1996, 18 (01) : 257 - 259
  • [13] LONG-TERM SIDE-EFFECTS IN CHILDREN RECEIVING ALLOGENEIC BONE-MARROW TRANSPLANTATION IN FIRST COMPLETE REMISSION OF ACUTE-LEUKEMIA
    THURET, I
    MICHEL, G
    CARLA, H
    CHAMBOST, H
    BLAISE, D
    DEMEOCQ, F
    MARANINCHI, D
    BONE MARROW TRANSPLANTATION, 1995, 15 (03) : 337 - 341
  • [14] A Comparison of Long-Term Outcomes of Donor Lymphocyte Infusions and Tyrosine Kinase Inhibitors in Patients With Relapsed CML After Allogeneic Hematopoietic Cell Transplantation
    Shanavas, Mohamed
    Messner, Hans A.
    Kamel-Reid, Suzanne
    Atenafu, Eshetu G.
    Gupta, Vikas
    Kuruvilla, John
    Kim, Dennis
    Uhm, Jieun
    Lambie, Anna
    Ellis, Laura
    Lipton, Jeffrey H.
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2014, 14 (01) : 87 - 92
  • [15] Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10 years
    Wada, Akinori
    Kobayashi, Naoki
    Asanuma, Shinsuke
    Matsuoka, Satomi
    Kosugi, Mizuha
    Fujii, Shiro
    Noguchi, Shinsuke
    Miyazono, Takayoshi
    Nakata, Masanobu
    Ota, Shuichi
    Imai, Kiyotoshi
    Hirano, Teiichi
    Ogasawara, Masahiro
    Kiyama, Yoshio
    Kasai, Masaharu
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2011, 93 (01) : 118 - 122
  • [16] Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for β-thalassemia major
    Aker, M
    Kapelushnik, J
    Pugatsch, T
    Naparstek, E
    Ben-Neria, S
    Yehuda, O
    Amar, A
    Nagler, A
    Slavin, S
    Or, R
    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 1998, 20 (02) : 145 - 148
  • [17] Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10 years
    Akinori Wada
    Naoki Kobayashi
    Shinsuke Asanuma
    Satomi Matsuoka
    Mizuha Kosugi
    Shiro Fujii
    Shinsuke Noguchi
    Takayoshi Miyazono
    Masanobu Nakata
    Shuichi Ota
    Kiyotoshi Imai
    Teiichi Hirano
    Masahiro Ogasawara
    Yoshio Kiyama
    Masaharu Kasai
    International Journal of Hematology, 2011, 93 : 118 - 122
  • [18] Does donor-recipient ABO incompatibility protect against relapse after allogeneic bone marrow transplantation in first remission acute myeloid leukemia?
    Mehta, J
    Powles, R
    Sirohi, B
    Treleaven, J
    Kulkarni, S
    Saso, R
    Tait, D
    Singhal, S
    BONE MARROW TRANSPLANTATION, 2002, 29 (10) : 853 - 859
  • [19] Long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: favorable outcome with BMT at first remission and HLA-matched unrelated donor
    Chim, C. S.
    Lie, A. K. W.
    Liang, R.
    Au, W. Y.
    Kwong, Y. L.
    BONE MARROW TRANSPLANTATION, 2007, 40 (04) : 339 - 347
  • [20] Long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: favorable outcome with BMT at first remission and HLA-matched unrelated donor
    C S Chim
    A K W Lie
    R Liang
    W Y Au
    Y L Kwong
    Bone Marrow Transplantation, 2007, 40 : 339 - 347
12345