Mucosal tolerance and immunity: Regulating the development of allergic disease and asthma

被引：39

作者：

Akbari, O ^{[1
]}

Stock, P ^{[1
]}

DeKruyff, RH ^{[1
]}

Umetsu, DT ^{[1
]}

机构：

[1] Stanford Univ, Dept Pediat, Div Immunol & Allergy, Stanford, CA 94305 USA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2003年 / 130卷 / 02期

关键词：

dendritic cells; costimulatory molecules; asthma; IL-10; tolerance;

D O I：

10.1159/000069012

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Allergic diseases and asthma are characterized by eosinophilic inflammation induced by Th2 lymphocytes. However, the immunological events and the molecular and cellular mechanisms that protect against and regulate these pathological immune responses are poorly understood. In this review, we discuss the role of immunological tolerance, regulatory T cells, and dendritic cells (DCs) in these protective processes. In addition, we discuss factors like the maturation state of DCs, source and effect of Il-10 production as well as specific combinations of costimulatory molecules in the antigen-presenting cell: T cell synapse, which determine whether tolerance or immunity develops in the respiratory mucosa in response to inhaled allergen. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：108 / 118

页数：11

共 116 条

[1] Characterization of human inducible costimulator ligand expression and function [J].

Aicher, A ;

Hayden-Ledbetter, M ;

Brady, WA ;

Pezzutto, A ;

Richter, G ;

Magaletti, D ;

Buckwalter, S ;

Ledbetter, JA ;

Clark, EA .

JOURNAL OF IMMUNOLOGY, 2000, 164 (09) :4689-4696

[2] Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen [J].

Akbari, O ;

DeKruyff, RH ;

Umetsu, DT .

NATURE IMMUNOLOGY, 2001, 2 (08) :725-731

[3]

Akbari O, 2002, NAT MED, V8, P1024, DOI 10.1038/nm745

[4] Role of interleukin 10 in specific immunotherapy [J].

Akdis, CA ;

Blesken, T ;

Akdis, M ;

Wüthrich, B ;

Blaser, K .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (01) :98-106

[5] Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis [J].

Akiba, H ;

Miyahira, Y ;

Atsuta, M ;

Takeda, K ;

Nohara, C ;

Futagawa, T ;

Matsuda, H ;

Aoki, T ;

Yagita, H ;

Okumura, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (02) :375-380

[6]

Arestides RSS, 2002, EUR J IMMUNOL, V32, P2874, DOI 10.1002/1521-4141(2002010)32:10<2874::AID-IMMU2874>3.0.CO

[7]

2-4

[8] Signaling through OX40 (CD134) breaks peripheral T-cell tolerance [J].

Bansal-Pakala, P ;

Jember, AGH ;

Croft, M .

NATURE MEDICINE, 2001, 7 (08) :907-912

[9] In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].

Barrat, FJ ;

Cua, DJ ;

Boonstra, A ;

Richards, DF ;

Crain, C ;

Savelkoul, HF ;

de Waal-Malefyt, R ;

Coffman, RL ;

Hawrylowicz, CM ;

O'Garra, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616

[10]

Beier KC, 2000, EUR J IMMUNOL, V30, P3707, DOI 10.1002/1521-4141(200012)30:12<3707::AID-IMMU3707>3.0.CO

← 1 2 3 4 5 6 7 8 9 10 →