Functional nanofibrous scaffolds for bone reconstruction

被引：26

作者：

Burger, Christian ^{[1
]}

Chu, Benjamin ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2007年 / 56卷 / 1-2期

基金：

美国国家科学基金会;

关键词：

gene delivery; biodegradable scaffolds; static light scattering;

D O I：

10.1016/j.colsurfb.2006.09.023

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

DNA compaction, encapsulation and stabilization strategies as well as a scheme for DNA chain stabilization by complex formation with modified fullerenes for gene delivery are discussed. DNA can be compacted in organic solvents and encapsulated with amphiphilic triblock copolymers. The rapid removal of the solvent mixtures by electrospinning together with a biodegradable polymer preserves the globular DNA conformation and can be used for bone reconstruction applications. Cationic fullerene surfactants can decorate and stabilize DNA coils in aqueous solution. The complex formation process is studied by static light scattering and analyzed in detail. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：134 / 141

页数：8

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