COVID-19, HHV6 and MOG antibody: A perfect storm

被引：21

作者：

Jumah, Muruj ^{[1
]}

Rahman, Farah ^{[2
]}

Figgie, Mark ^{[1
]}

Prasad, Ankita ^{[1
]}

Zampino, Anthony ^{[1
]}

Fadhil, Ali ^{[1
]}

Palmer, Kaitlin ^{[1
]}

Buerki, Robin Arthur ^{[1
,2
]}

Gunzler, Steven ^{[1
,2
]}

Gundelly, Praveen ^{[2
,3
]}

Abboud, Hesham ^{[1
,2
,4
]}

机构：

[1] Univ Hosp Cleveland, Neurol Dept, Cleveland, OH USA

[2] Case Western Reserve Univ, Sch Med, Cleveland, OH USA

[3] Univ Hosp Cleveland, Infect Dis Dept, Cleveland, OH USA

[4] Univ Hosp Cleveland, Multiple Sclerosis & Neuroimmunol Program, Cleveland, OH USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 353卷

关键词：

COVID-19; SARS-CoV-2; HHV6; MOG; Transverse myelitis; Demyelination; OPTIC NEURITIS; MYELITIS;

D O I：

10.1016/j.jneuroim.2021.577521

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Serious neurological complications of SARS-CoV-2 are increasingly being recognized. Case: We report a novel case of HHV6 myelitis with parainfectious MOG-IgG in the setting of COVID-19-induced lymphopenia and hypogammaglobulinemia. The patient experienced complete neurological recovery with gancyclovir, high dose corticosteroids, and plasma exchange. To our knowledge, this is the first case of HHV6 reactivation in the central nervous system in the setting of COVID19 infection and the first case of MOG-IgG myelitis in the setting of SARS-CoV-2 and HHV6 coinfection. Conclusion: Patients with neurological manifestations in the setting of COVID19-related immunodeficiency should be tested for opportunistic infections including HHV6. Viral infection is a known trigger for MOG-IgG and therefore this antibody should be checked in patients with SARS-CoV-2 associated demyelination.

引用

页数：5

共 28 条

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