miR-219 inhibits the growth and metastasis of TSCC cells by targeting PRKCI

被引：1

作者：

Song, Kai-Bin ^{[1
]}

Liu, Wen-Juan ^{[2
]}

Jia, Shen-Shan ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Head & Neck Surg, Affiliated Hosp 3, Harbin 150081, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Dept Neurol, Affiliated Hosp 2, Harbin 150001, Heilongjiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2014年 / 7卷 / 09期

关键词：

TSCC; miR-219; PRKCI; growth; metastasis; KINASE-C-IOTA; TUMOR-SUPPRESSOR; PROSTATE-CANCER; CARCINOMA; ONCOGENE;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tongue squamous cells carcinoma (TSCC) is the most common type in oral cancers. Recently, accumulating evidence suggests that microRNAs (miRNAs) play critical roles in tumorigenesis. Here, we demonstrated that miR-219 was significantly downregulated in TSCC tissues and cell lines. miR-219 overexpression remarkably suppressed cell proliferation, colony formation, migration and invasion of TSCC cells. In addition, protein kinase CI (PRKCI) was identified as a target of miR-219, and overexpression of PRKCI could significantly attenuated the tumor suppressive effects of miR-219. Furthermore, PRKCI inversely correlates with miR-219 in TSCC tissues. Taken together, miR-219 inhibited growth and metastasis by targeting PRKCI and might be used as a potential target for the treatment of TSCC.

引用

收藏

页码：2957 / 2965

页数：9

相关论文

共 21 条

[1]

[Anonymous], INT J CANC

[2] Genetic variability in the PRKCI gene and prostate cancer risk [J].

Campa, Daniele ;

Canzian, Federico ;

Kaaks, Rudolf .

CELL CYCLE, 2012, 11 (02) :209-209

[3] Protein kinase Cι:: Human oncogene, prognostic marker and therapeutic target [J].

Fields, Alan P. ;

Regala, Roderick P. .

PHARMACOLOGICAL RESEARCH, 2007, 55 (06) :487-497

[4] Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer [J].

Frederick, L. A. ;

Matthews, J. A. ;

Jamieson, L. ;

Justilien, V. ;

Thompson, E. A. ;

Radisky, D. C. ;

Fields, A. P. .

ONCOGENE, 2008, 27 (35) :4841-4853

[5] MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3 [J].

Huang, Na ;

Lin, Jing ;

Ruan, Jian ;

Su, Ning ;

Qing, Ruzhai ;

Liu, Feiye ;

He, Benfu ;

Lv, Chengwei ;

Zheng, Dayong ;

Luo, Rongcheng .

FEBS LETTERS, 2012, 586 (06) :884-891

[6] Ect2 links the PKCι-Par6α complex to Rac1 activation and cellular transformation [J].

Justilien, V. ;

Fields, A. P. .

ONCOGENE, 2009, 28 (41) :3597-3607

[7] The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma [J].

Justilien, Verline ;

Walsh, Michael P. ;

Ali, Syed A. ;

Thompson, E. Aubrey ;

Murray, Nicole R. ;

Fields, Alan P. .

CANCER CELL, 2014, 25 (02) :139-151

[8] Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer [J].

Kong, W. ;

He, L. ;

Richards, E. J. ;

Challa, S. ;

Xu, C-X ;

Permuth-Wey, J. ;

Lancaster, J. M. ;

Coppola, D. ;

Sellers, T. A. ;

Djeu, J. Y. ;

Cheng, J. Q. .

ONCOGENE, 2014, 33 (06) :679-689

[9] miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer [J].

Lahdaoui, F. ;

Delpu, Y. ;

Vincent, A. ;

Renaud, F. ;

Messager, M. ;

Duchene, B. ;

Leteurtre, E. ;

Mariette, C. ;

Torrisani, J. ;

Jonckheere, N. ;

Van Seuningen, I. .

ONCOGENE, 2015, 34 (06) :780-788

[10] RETRACTED: MicroRNA-219-2-3p Functions as a Tumor Suppressor in Gastric Cancer and Is Regulated by DNA Methylation (Retracted Article) [J].

Lei, Huizi ;

Zou, Dongling ;

Li, Zheng ;

Luo, Min ;

Dong, Lei ;

Wang, Bin ;

Yin, Haixin ;

Ma, Yanni ;

Liu, Changzheng ;

Wang, Fang ;

Zhang, Junwu ;

Yu, Jia ;

Li, Yu .

PLOS ONE, 2013, 8 (04)