β-lactamase epidemiology and the utility of established and novel β-lactamase inhibitors

被引:43
作者
Payne, DJ
Du, WS
Bateson, JH
机构
[1] SmithKline Beecham Pharmaceut, Antiinfect Res UP 1345, Collegeville, PA 19426 USA
[2] SmithKline Beecham Pharmaceut, Med Chem H34 1 045, Harlow CM19 5AW, Essex, England
关键词
beta-lactamases; beta-lactamase inhibitors; metallo-beta-lactamases; novel beta-lactamase inhibitors;
D O I
10.1517/13543784.9.2.247
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
beta-lactamase inhibitor: beta-lactam combinations remain one of the most successful strategies for the treatment of bacterial infections. Over the last 20 years the number and diversity of serine and metallo active site beta-lactamases has increased dramatically. This review highlights some of the new additions to the beta-lactamase arena and discusses how the commercially available beta-lactamase inhibitors are keeping pace with the changing epidemiology of beta-lactamases. In addition, we survey the progress with the design of novel inhibitors of serine and metallo-beta-lactamases. Focus is given to the recent advances in the design of metallo-beta-lactamase inhibitors as these enzymes pose a serious emerging threat to the use of all beta-lactam based therapies.
引用
收藏
页码:247 / 261
页数:15
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