Co-transcriptional monitoring of mRNP formation

被引：19
|
作者：
Jensen, TH [1 ]
Rosbash, M
机构：
[1] Aarhus Univ, Dept Biol Mol & Struct, DK-8000 Aarhus C, Denmark
[2] Brandeis Univ, Howard Hughes Med Inst, Dept Biol, Waltham, MA 02454 USA
来源：
NATURE STRUCTURAL BIOLOGY | 2003年 / 10卷 / 01期
关键词：
D O I：
10.1038/nsb0103-10
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In eukaryotes, newly manufactured mRNA is subject to strict quality control. If certain standards are not met, offending messages are retained in the nucleus and degraded by the exosome complex. New data suggest that exosome-mediated processes are intimately coupled to the transcription machinery, which makes the mRNA in the first place.
引用
收藏
页码：10 / 12
页数：3
相关论文
共 50 条
  • [31] Co-transcriptional architecture in a Y loop in Drosophila melanogaster
    Juliet L. Redhouse
    Julien Mozziconacci
    Robert A. H. White
    Chromosoma, 2011, 120 : 399 - 407
  • [32] Mimicking Co-Transcriptional RNA Folding using a Superhelicase
    Hua, Boyang
    Panja, Subrata
    Woodson, Sarah
    Ha, Taekjip
    BIOPHYSICAL JOURNAL, 2018, 114 (03) : 433A - 434A
  • [33] Structure, folding and flexibility of co-transcriptional RNA origami
    Ewan K. S. McRae
    Helena Østergaard Rasmussen
    Jianfang Liu
    Andreas Bøggild
    Michael T. A. Nguyen
    Nestor Sampedro Vallina
    Thomas Boesen
    Jan Skov Pedersen
    Gang Ren
    Cody Geary
    Ebbe Sloth Andersen
    Nature Nanotechnology, 2023, 18 : 808 - 817
  • [34] Co-transcriptional splicing facilitates transcription of gigantic genes
    Fingerhut, Jaclyn M.
    Lannes, Romain
    Whitfield, Troy W.
    Thiru, Prathapan
    Yamashita, Yukiko M.
    PLOS GENETICS, 2024, 20 (06):
  • [35] Co-transcriptional spliceosome assembly on mammalian model genes
    Bardehle, N. I.
    Neugebauer, K. M.
    NEW BIOTECHNOLOGY, 2010, 27 : S33 - S34
  • [36] Co-transcriptional commitment to alternative splice site selection
    Roberts, GC
    Gooding, C
    Mak, HY
    Proudfoot, NJ
    Smith, CWJ
    NUCLEIC ACIDS RESEARCH, 1998, 26 (24) : 5568 - 5572
  • [37] Mimicking Co-Transcriptional RNA Folding Using a Superhelicase
    Woodson, Sarah A. (swoodson@jhu.edu), 1600, American Chemical Society (140):
  • [38] Macromolecular Complexes in Transcription and Co-Transcriptional RNA Processing
    Passmore, Lori A.
    Taatjes, Dylan J.
    JOURNAL OF MOLECULAR BIOLOGY, 2016, 428 (12) : 2539 - 2541
  • [39] RNA METABOLISM Co-transcriptional splicing at nucleotide resolution
    Zlotorynski, Eytan
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2016, 17 (05) : 264 - 265
  • [40] Pseudouridylation: A new player in co-transcriptional splicing regulation
    Sousa-Luis, Rui
    Carmo-Fonseca, Maria
    MOLECULAR CELL, 2022, 82 (03) : 495 - 496
12345