Co-transcriptional monitoring of mRNP formation

被引：19
|
作者：
Jensen, TH [1 ]
Rosbash, M
机构：
[1] Aarhus Univ, Dept Biol Mol & Struct, DK-8000 Aarhus C, Denmark
[2] Brandeis Univ, Howard Hughes Med Inst, Dept Biol, Waltham, MA 02454 USA
来源：
NATURE STRUCTURAL BIOLOGY | 2003年 / 10卷 / 01期
关键词：
D O I：
10.1038/nsb0103-10
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In eukaryotes, newly manufactured mRNA is subject to strict quality control. If certain standards are not met, offending messages are retained in the nucleus and degraded by the exosome complex. New data suggest that exosome-mediated processes are intimately coupled to the transcription machinery, which makes the mRNA in the first place.
引用
收藏
页码：10 / 12
页数：3
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