Innate lymphoid cell development

被引：27

作者：

Ghaedi, Maryam ^{[1
]}

Takei, Fumio ^{[2
,3
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

[2] Univ British Columbia UBC, Dept Pathol & Lab Med, Vancouver, BC, Canada

[3] BC Canc, Terry Fox Lab, Vancouver, BC, Canada

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2021年 / 147卷 / 05期

关键词：

Innate lymphoid cells; ILCs; development; transcription factors; progenitors; NATURAL-KILLER-CELL; TRANSCRIPTION FACTOR GATA3; ARYL-HYDROCARBON RECEPTOR; TISSUE-INDUCER CELL; T-CELL; LINEAGE COMMITMENT; IL-33; PROMOTES; FACTOR BCL11B; HELPER-CELLS; STEM-CELL;

D O I：

10.1016/j.jaci.2021.03.009

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and regulate tissue homeostasis and immunity. ILCs are divided into 3 groups, group 1 ILCs, group 2 ILCs, and group 3 ILC3, on the basis of their similar effector programs to T cells. The development of ILCs from lymphoid progenitors in adult mouse bone marrow has been studied in detail, and multiple ILC progenitors have been characterized. ILCs are mostly tissue-resident cells that develop in the perinatal period. More recently, ILC progenitors have also been identified in peripheral tissues. In this review, we discuss the stepwise transcription factor-directed differentiation of mouse ILC progenitors into mature ILCs, the critical time windows in ILC development, and the contribution of bone marrow versus tissue ILC progenitors to the pool of mature ILCs in tissues. (J Allergy Clin Immunol 2021;147:1549-60.)

引用

页码：1549 / 1560

页数：12

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