PhI(OAc)2-Mediated Dihalogenative Cyclization of 1,6-Enyne with Lithium Halide

被引：24

作者：

Dong, Ming ^{[1
]}

Wang, Danfeng ^{[1
]}

Tong, Xiaofeng ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 09期

关键词：

CATALYZED OXIDATIVE CYCLIZATION; ANNULATION; ENYNES; N-ENYNES; CYCLOISOMERIZATION; FUNCTIONALIZATION; CARBOCYCLIZATION; ALKYNES;

D O I：

10.1021/acs.orglett.1c00987

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The dihalogenative cyclization of 1,6-enyne with the assistance of PhI(OAc)(2) and lithium halide is presented. A plausible radical mechanism is proposed, which consists of addition of halogen radical to alkene, 5-exo-dig radical cyclization of enyne and halogenation via radical coupling. The alkenyl- and alkyl-halide groups in the resulted pyrrolidine products have been demonstrated to be facile handles for further transformations.

引用

页码：3588 / 3592

页数：5

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