Synthesis of Isocoumarins through Three-Component Couplings of Arynes, Terminal Alkynes, and Carbon Dioxide Catalyzed by an NHC-Copper Complex

被引：95
|
作者：
Yoo, Woo-Jin [1 ]
Nguyen, Thanh V. Q. [1 ]
Kobayashi, Shu [1 ]
机构：
[1] Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 38期
基金：
日本科学技术振兴机构; 日本学术振兴会;
关键词：
alkynes; arynes; carbon dioxide; copper; multicomponent reactions; 3-SUBSTITUTED ISOCOUMARINS; INTRAMOLECULAR CYCLIZATION; ACID-DERIVATIVES; CARBOXYLIC-ACIDS; BENZOIC-ACIDS; H BONDS; CO2; TRANSFORMATION; ESTERS; PHTHALIDES;
D O I：
10.1002/anie.201404692
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A copper-catalyzed multicomponent coupling reaction between in situ generated ortho-arynes, terminal alkynes, and carbon dioxide was developed to access isocoumarins in moderate to good yields. The key to this CO2-incorporating reaction was the use of a versatile N-heterocyclic carbene/copper complex that was able to catalyze multiple transformations within the three-component reaction.
引用
收藏
页码：10213 / 10217
页数：5
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