Ustekinumab-induced chronic lymphocytic leukemia in a patient with psoriatic arthritis

被引：1
作者：
Gediz, Fusun [1 ]
Ugur, Mehmet Can [1 ]
Turkmen, Meltem [2 ]
Kobak, Senol [3 ]
机构：
[1] Univ Hlth Sci, Izmir Bozyaka Training & Res Hosp, Dept Hematol, Izmir, Turkey
[2] Univ Hlth Sci, Izmir Bozyaka Training & Res Hosp, Dept Dermatol, Izmir, Turkey
[3] Istinye Univ, LIV Hosp, Fac Med, Dept Rheumatol, Istanbul, Turkey
来源：
REUMATOLOGIA | 2021年 / 59卷 / 01期
关键词：
Chronic lymphocytic leukemia; Psoriatic arthritis; Ustekinumab;
D O I：
10.5114/reum.2021.102618
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by skin and joint involvement. The disease may present with various joint pattern involvement, which sometimes may lead to joint destruction and deformity. Early diagnosis and treatment with disease-modifying antirheumatic drugs may prevent joint deformity. Recently there are many new treatment options including biologic drugs. Ustekinumab, an interleukin 12/23 inhibitor, has proven efficacy in the treatment of psoriatic arthritis. Like other biologic drugs (anti-TNF-alpha), there are contradictory data about the safety of ustekinumab and possible relationship with cancer development. Herein we report the development of chronic lymphocytic leukemia in a patient with PsA treated with ustekinumab.
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页码：58 / 61
页数：4
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