Ubc9 deficiency selectively impairs the functionality of common lymphoid progenitors (CLPs) during bone marrow hematopoiesis

被引：4

作者：

Edrees, Mohammed Abdelssalam Hassan ^{[1
]}

Luo, Jiahui ^{[1
]}

Sun, Fei ^{[1
]}

Wang, Faxi ^{[1
]}

He, Long ^{[1
,2
]}

Yue, Tiantian ^{[1
]}

Chen, Longmin ^{[1
]}

Zhang, Jing ^{[1
]}

Zhou, Haifeng ^{[1
]}

Yang, Chunliang ^{[1
]}

Yang, Ping ^{[1
]}

Xiong, Fei ^{[1
]}

Yu, Qilin ^{[1
]}

Adam, Bao-Ling ^{[3
]}

Liu, Furong ^{[4
]}

Li, Jinxiu ^{[5
]}

Zhang, Shu ^{[1
]}

Wang, Cong-Yi ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Ctr Biomed Res, Tongji Hosp Res Bldg, Wuhan 430030, Hubei, Peoples R China

[2] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Lab, 150 Ji Mo Rd, Shanghai 200120, Peoples R China

[3] Augusta Univ, Med Coll Georgia, Dept Surg, 1120 15th St,BI-4074, Augusta, GA 30912 USA

[4] Peoples Hosp Shishou City, Dept Dermatol, Shishou, Hubei, Peoples R China

[5] Shenzhen Third Peoples Hosp, 29 Bulan Rd, Shenzhen 518000, Guangdong, Peoples R China

来源：

MOLECULAR IMMUNOLOGY | 2019年 / 114卷

基金：

中国国家自然科学基金;

关键词：

Ubc9; Hematopoietic development; Common lymphoid progenitors; UBIQUITIN-CONJUGATING ENZYME; SELF-RENEWAL; SUMO; MOUSE; CELLS; DIFFERENTIATION; GENERATION; HDAC1;

D O I：

10.1016/j.molimm.2019.08.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hematopoietic development occurs in the bone marrow, and this process begins with hematopoietic stem cells (HSCs). Ubc9 is a unique E2-conjugating enzyme required for SUMOylation, an evolutionarily conserved post-translational modification system. We herein show that a conditional Ubc9 deletion in the hematopoietic system caused decreased thymus weight and reduced lymphocyte to myeloid cell ratio. Importantly, Ubc9 deletion in the hematopoietic system only selectively impaired the development of common lymphoid progenitors (CLPs) in the bone marrow and perturbed their potential to differentiate into lymphocytes, thereby decreasing the number of T/B cells in the periphery. Ubc9 was found to be required for CLP viability, and therefore, Ubc9 deficiency rendered CLPs to undergo apoptosis and attenuated their proliferation. Thus, Ubc9 plays a critical role in the regulation of CLP function during hematopoietic development in the bone marrow.

引用

页码：314 / 322

页数：9

共 33 条

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