Multifocal signal modulation therapy of cancer: ancient weapon, modern targets

被引：47

作者：

Das, Tanya ^{[1
]}

Sa, Gaurisankar ^{[1
]}

Saha, Baisakhi ^{[1
]}

Das, Kaushik ^{[1
]}

机构：

[1] Bose Inst, Div Mol Med, Kolkata 700054, India

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2010年 / 336卷 / 1-2期

关键词：

Apoptosis; Angiogenesis; Cancer; Cell signaling; Curcumin; Metastasis; Survival; FACTOR-KAPPA-B; T-CELL APOPTOSIS; CHEMOPREVENTIVE AGENT CURCUMIN; ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; MOUSE MELANOMA-CELLS; HUMAN BREAST-CANCER; N-TERMINAL KINASE; I CLINICAL-TRIAL; PANCREATIC-CANCER;

D O I：

10.1007/s11010-009-0269-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although safe in most cases, ancient treatments are ignored because neither their active components nor their molecular targets are well defined. This is not the case, however, with curcumin, a yellow-pigment substance and component of turmeric (Curcuma longa), which was identified more than a century ago. Recently, extensive research has addressed the chemotherapeutic potential of this relatively nontoxic-plant-derived polyphenol. Because most cancers are caused by deregulation of as many as 500 different genes, agents that target multiple gene products are needed for prevention and treatment of cancer. In this regard, curcumin has been reported to have immense potentiality for being used in cancer chemotherapy because of its control over the machineries of cell survival, proliferation, invasion, and angiogenesis. The mechanisms implicated are diverse and appear to involve a combination of cell signaling pathways at multiple levels. This review seeks to summarize the unique multifocal signal modulatory properties of the "ancient weapon," curcumin, which may be exploited for successful clinical cancer prevention.

引用

页码：85 / 95

页数：11

共 87 条

[1] Curcumin suppresses the paclitaxel-induced nuclear factor-κB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice [J].