Obligatory role of NR2A for metaplasticity in visual cortex

被引：155
作者：
Philpot, Benjamin D.
Cho, Kathleen K. A.
Bear, Mark F.
机构：
[1] MIT, Picower Inst Learning & Memory, Howard Hughes Med Inst, Cambridge, MA 02139 USA
[2] Univ N Carolina, Ctr Neurosci, Curriculum Neurobiol, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA
来源：
NEURON | 2007年 / 53卷 / 04期
关键词：
D O I：
10.1016/j.neuron.2007.01.027
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Light deprivation lowers the threshold for long-term depression (LTD) and long-term potentiation (LTP) in visual cortex by a process termed metaplasticity, but the mechanism is unknown. The decreased LTD/P threshold correlates with a decrease in the ratio of NR2A to NR2B subunits of cortical NMDA receptors (NMDARs) and a slowing of NMDAR-mediated excitatory postsynaptic currents (EPSCs). However, whether and how changes in NR2 subunit expression contribute to LTD and LTP have been controversial. In the present study, we used an NR2A knockout (KO) mouse to examine the role of this subunit in the experience-dependent modulation of NMDAR properties, LTD, and LTP. We found that deletion of NR2A abrogates the effects of visual experience on NMDAR EPSCs and prevents metaplasticity of LTP and LTD. These data support the hypothesis that experience-dependent changes in NR2A/B are functionally significant and yield a mechanism for an adjustable synaptic modification threshold in visual cortex.
引用
收藏
页码：495 / 502
页数：8
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