The effect of glycine filler on the elution rate of gentamicin from acrylic bone cement - A pilot study

被引：35

作者：

McLaren, AC ^{[1
]}

Nelson, CL ^{[1
]}

McLaren, SG ^{[1
]}

DeClerk, GR ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Dept Orthopaed Surg, Little Rock, AR 72205 USA

来源：

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH | 2004年 / 427期

关键词：

D O I：

10.1097/01.blo.0000143556.41472.2a

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Elution of antibiotics from acrylic bone cement (polymethylmethacrylate [PMMA]) is dependent on the access of fluid to the depths of the cement that contains the antibiotic. Commercially prepared antibiotic beads that are porous have higher elution rates than hand-mixed, nonporous antibiotic PMMA mixtures. To increase the elution of gentamicin from hand-mixed PMMA, glycine was added as a filler to produce porosity. Elution of gentamicin from the antibiotic PMMA-glycine mixture increased with increasing amounts of glycine. With 3.6 g gentamicin powder and 14 g of crystalline glycine per batch of Palacos PMMA, the elution of gentamicin from the PMMA at 2 days was, similar to the previously documented elution of gentamicin from commercially prepared porous Septopal PMMA beads. With further investigation it may be possible to identify a specific filler and a volume of filler that can be hand mixed in antibiotic PMMA to produce the elution behavior that is needed for specific clinical requirements.

引用

页码：25 / 27

页数：3