Prostate cancer in black and white Americans

被引:50
作者
Reddy, S [1 ]
Shapiro, M
Morton, R
Brawley, OW
机构
[1] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA
[2] Baylor Sch Med, Dept Urol, Houston, TX USA
关键词
prostate cancer; race; genetics; outcomes; hormones;
D O I
10.1023/A:1022216119066
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The prostate cancer incidence and mortality of black Americans is among the highest in the world. The reasons have not been adequately explained. Similar disparities have been noted for men of sub-Saharan origin living in Brazil and the Caribbean. Avenues of investigation have assessed racial and ethnic differences in diet as well as possible differences in the prevalence of genetics (both polymorphisms and mutations). There are studies to suggest that there are no racial differences in outcome when there is equal treatment. Several studies show that there are racial differences in patterns of care in the US and it has been hypothesized that this contributes to some of the racial disparity in survival after diagnosis.
引用
收藏
页码:83 / 86
页数:4
相关论文
共 30 条
[21]  
2-1
[22]   TREATMENT OF LOCALIZED PROSTATE-CANCER IN AFRICAN-AMERICAN COMPARED WITH CAUCASIAN MEN - LESS USE OF AGGRESSIVE THERAPY FOR COMPARABLE DISEASE [J].
SCHAPIRA, MM ;
MCAULIFFE, TL ;
NATTINGER, AB .
MEDICAL CARE, 1995, 33 (11) :1079-1088
[23]   Polymorphisms in the androgen receptor and type II 5α-reductase genes and prostate cancer prognosis [J].
Shibata, A ;
Garcia, MI ;
Cheng, I ;
Stamey, TA ;
McNeal, JE ;
Brooks, JD ;
Henderson, S ;
Yemoto, CE ;
Peehl, DM .
PROSTATE, 2002, 52 (04) :269-278
[24]   5α-Reductase 2 polymorphisms as risk factors in prostate cancer [J].
Söderström, T ;
Wadelius, M ;
Andersson, SO ;
Johansson, JE ;
Johansson, S ;
Granath, F ;
Rane, A .
PHARMACOGENETICS, 2002, 12 (04) :307-312
[25]   Association of African-American ethnic background with survival in men with metastatic prostate cancer [J].
Thompson, IM ;
Tangen, CM ;
Tolcher, A ;
Crawford, ED ;
Eisenberger, M ;
Moinpour, CM .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (03) :219-225
[26]  
Washburn JG, 2000, CLIN CANCER RES, V6, P4647
[27]   PROSTATE-CANCER IN RELATION TO DIET, PHYSICAL-ACTIVITY, AND BODY-SIZE IN BLACKS, WHITES, AND ASIANS IN THE UNITED-STATES AND CANADA [J].
WHITTEMORE, AS ;
KOLONEL, LN ;
WU, AH ;
JOHN, EM ;
GALLAGHER, RP ;
HOWE, GR ;
BURCH, JD ;
HANKIN, J ;
DREON, DM ;
WEST, DW ;
TEH, CZ ;
PAFFENBARGER, RS .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (09) :652-661
[28]  
WU AH, 1995, CANCER EPIDEM BIOMAR, V4, P735
[29]  
Yang G, 2000, CLIN CANCER RES, V6, P3430
[30]  
Young C D, 2000, Semin Urol Oncol, V18, P121