Structure of a CBS-domain pair from the regulatory γ1 subunit of human AMPK in complex with AMP and ZMP

被引：77
作者：
Day, Philip
Sharff, Andrew
Parra, Lina
Cleasby, Anne
Williams, Mark
Hoerer, Stefan
Nar, Herbert
Redemann, Norbert
Tickle, Ian
Yon, Jeff
机构：
[1] Astex Therapeut Ltd, Cambridge CB4 0QA, England
[2] Boehringer Ingelheim Pharma GmbH & Co KG, D-88397 Biberach, Germany
来源：
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2007年 / 63卷
关键词：
D O I：
10.1107/S0907444907009110
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit. The structure of a CBS-domain pair from human AMPK yl in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.
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收藏
页码：587 / 596
页数：10
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