The extensive use of the Information Systems (IS), whose meaning has been growing in diversity and complexity, lead to considerate a new conceptual framework for their development, defined as informing Science (InfoS). The paper examines the limitations of existing frameworks for defining IS and introduces a new evolutionary approach to state the InfoS definition. To understand InfoS role, the paper analyses the relation between "knowledge" and "information" as these notions appear in the field of Information Technology. Finally some suggestions for the placement the Informing Science in universitary study curricula are discussed, as well as its method of segmenting knowledge creation and dissemination.