Synthesis of 3-Chloro-3-(trimethylsilyl)prop-2-enoic Acid Amides and Hydrazides from 3-(Trimethylsilyl)propynoic Acid

被引：0
|
作者：
Andreev, M., V [1 ]
Demina, M. M. [1 ]
Medvedeva, A. S. [1 ]
Safronova, L. P. [1 ]
Albanov, A., I [1 ]
Afonin, A., V [1 ]
机构：
[1] Russian Acad Sci, Favorsky Irkutsk Inst Chem, Siberian Branch, Irkutsk 664033, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 57卷 / 04期
关键词：
amides; hydrazides; acylation; chlorination; 3-(trimethylsilyl)propynoic acid; amines; amino alcohols; leucine; vinyl chlorides; BAYLIS-HILLMAN REACTION; 2,3-ACETYLENIC ACIDS; FACILE SYNTHESIS; ACRYLAMIDE; CONDENSATION; CHLORIDE; LACTAM;
D O I：
10.1134/S1070428021040102
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A number of previously unknown and difficultly accessible polyfunctional ss-chloro-ss-(trimethylsilyl)prop-2-enoic acid amides and hydrazides have been synthesized by amination of 3-chloro-3-(trimethylsilyl)prop-2-enoyl chloride with the corresponding amines, amino alcohols, 2-amino-4-methylpentanoic acid, and hydrazines. Initial 3-chloro-3-(trimethylsilyl)prop-2-enoyl chloride has been prepared by hydrohalogenation of 3-trimethylsilylpropynoic acid with thionyl chloride in DMF, followed by treatment with oxalyl chloride.
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收藏
页码：565 / 574
页数：10
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