Smoking Behavior and Exposure: Results of a Menthol Cigarette Cross-over Study

被引:30
作者
Watson, Christina Vaughan [1 ]
Richter, Patricia [1 ]
de Castro, B. Rey [1 ]
Sosnoff, Connie [1 ]
Potts, Jennifer [3 ]
Clark, Pamela [2 ]
McCraw, Joan [1 ]
Yan, Xizheng [1 ]
Chambers, David [1 ]
Watson, Clifford [1 ]
机构
[1] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA
[2] Univ Maryland, College Pk, MD 20742 USA
[3] Battelle Mem Inst, Baltimore, MD USA
关键词
menthol cigarettes; smoking; addiction; smoking behavior; nicotine; NICOTINE DEPENDENCE; NONMENTHOL SMOKERS; TOBACCO-SMOKE; CESSATION; COTININE; 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANOL; METABOLISM; RECEPTOR; SAMPLES; WOMEN;
D O I
10.5993/AJHB.41.3.10
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective: Our objective was to improve understanding of the differences in use behavior and exposure when smoking menthol and non-menthol cigarettes using a 2-part cross-over design. Methods: Adult daily smokers were assigned randomly to alternate between 2 weeks of exclusively smoking a menthol test cigarette or a non-menthol test cigarette. Urine and saliva were collected for biomarker measurements; carbon monoxide (CO) was measured, and participants smoked test cigarettes through a CreSS (R) smoking topography device during 3 clinic visits. Participants turned in their cigarette butts from the test periods for determination of mouth level nicotine and completed subjective questionnaires related to the test cigarettes. Results: Regardless of cigarette preference, participants had higher salivary cotinine when smoking the non-menthol test cigarette, but there were no significant differences detected in urine 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanol between the 2 test cigarettes. Mouth level nicotine, puff volume, and puff duration were significantly higher when smoking the menthol brand. Both menthol and non-menthol smokers reported significantly lower enjoyment and satisfaction scores for test cigarettes compared with their brand of choice. Conclusions: Our results suggest that mentholation has an effect on measures of smoking behavior and that mouth level nicotine is a useful indicator of between-brand smoke exposure.
引用
收藏
页码:309 / 319
页数:11
相关论文
共 41 条
[1]  
Abt Associates for the Massachusetts Department of Health (MDOH), 7 MDOH ABT ASS
[2]   Smoke constituent exposure and stage of change in black and white women cigarette smokers [J].
Ahijevych, K ;
Parsley, LA .
ADDICTIVE BEHAVIORS, 1999, 24 (01) :115-120
[3]   Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice [J].
Alsharari, Shakir D. ;
King, Justin R. ;
Nordman, Jacob C. ;
Muldoon, Pretal P. ;
Jackson, Asti ;
Zhu, Andy Z. X. ;
Tyndale, Rachel F. ;
Kabbani, Nadine ;
Damaj, M. Imad .
PLOS ONE, 2015, 10 (09)
[4]  
[Anonymous], 2009, ENFORCEMENT GEN TOBA, P49874
[5]  
[Anonymous], 2008, IARC HDB CANC PREV
[6]   The menthol receptor TRPM8 is the principal detector of environmental cold [J].
Bautista, Diana M. ;
Siemens, Jan ;
Glazer, Joshua M. ;
Tsuruda, Pamela R. ;
Basbaum, Allan I. ;
Stucky, Cheryl L. ;
Jordt, Sven-Eric ;
Julius, David .
NATURE, 2007, 448 (7150) :204-208
[7]   Mentholated cigarette smoking inhibits nicotine metabolism [J].
Benowitz, NL ;
Herrera, B ;
Jacob, P .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 310 (03) :1208-1215
[8]   Comparison of serum and salivary cotinine measurements by a sensitive high-performance liquid chromatography-tandem mass spectrometry method as an indicator of exposure to tobacco smoke among smokers and nonsmokers [J].
Bernert, JT ;
McGuffey, JE ;
Morrison, MA ;
Pirkle, JL .
JOURNAL OF ANALYTICAL TOXICOLOGY, 2000, 24 (05) :333-339
[9]   Exposure to and deposition of fine and ultrafine particles in smokers of menthol and nonmenthol cigarettes [J].
Brinkman, Marielle C. ;
Chuang, Jane C. ;
Gordon, Sydney M. ;
Kim, Hyoshin ;
Kroeger, Robyn R. ;
Polzin, Gregory M. ;
Richter, Patricia A. .
INHALATION TOXICOLOGY, 2012, 24 (05) :255-269
[10]   Menthol cigarettes and risk of lung cancer [J].
Brooks, DR ;
Palmer, JR ;
Strom, BL ;
Rosenberg, L .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2003, 158 (07) :609-616