Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β

被引：153

作者：

Mormino, Elizabeth C. ^{[1
]}

Papp, Kathryn V. ^{[1
,2
]}

Rentz, Dorene M. ^{[1
,2
]}

Donohue, Michael C. ^{[3
]}

Amariglio, Rebecca ^{[1
,2
]}

Quiroz, Yakeel T. ^{[1
,4
,5
]}

Chhatwal, Jasmeer ^{[1
]}

Marshall, Gad A. ^{[1
,2
]}

Donovan, Nancy ^{[5
]}

Jackson, Jonathan ^{[1
]}

Gatchel, Jennifer R. ^{[5
]}

Hanseeuw, Bernard J. ^{[1
]}

Schultz, Aaron P. ^{[4
,6
]}

Aisen, Paul S. ^{[3
]}

Johnson, Keith A. ^{[1
,2
,6
,7
]}

Sperling, Reisa A. ^{[1
,2
,6
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, Boston, MA 02115 USA

[3] Univ Southern Calif, Alzheimers Therapeut Res Inst, Dept Neurol, San Diego, CA USA

[4] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol, Charlestown, MA USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA

[6] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02115 USA

[7] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA USA

来源：

ALZHEIMERS & DEMENTIA | 2017年 / 13卷 / 09期

关键词：

Preclinical Alzheimer's disease; Secondary prevention; Cognitive composite; Amyloid PET; Longitudinal cognitive decline; PREVENTION TRIAL; DISEASE; DECLINE; DEMENTIA; MEMORY; AD; TRAJECTORIES; IMPAIRMENT; PREDICTION; BIOMARKERS;

D O I：

10.1016/j.jalz.2017.01.018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Sensitive detection of cognitive decline over the course of preclinical Alzheimer's disease is critical as the field moves toward secondary prevention trials. Methods: We examined amyloid beta (A beta)-related change in several variations of the preclinical Alzheimer cognitive composite (PACC) and each individual PACC component in clinically normal (CN) older participants in the Harvard Aging Brain Study. We then examined the PACC variations in the Alzheimer's Disease Cooperative Study Prevention Instrument Study as a replication cohort. Results: A beta+ CN individuals demonstrated longitudinal decline on all individual PACC components and all PACC variations. Ab group differences emerged earlier when Free and Cued Selective Reminding Test Free Recall was included in the PACC. PACC decline was associated with Clinical Dementia Rating progression. Discussion: This independent data set and a replication cohort confirm the ability of the PACC to capture both early and late cognitive decline during the preclinical stages of Alzheimer's disease, which may prove advantageous in the prevention trial design. (C) 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：1004 / 1012

页数：9

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