Research Progress in Structural Modification of Antimycin A

被引：3

作者：

Cheng, Hua ^{[1
]}

Nie, Ren ^{[1
]}

Wang, Wangqiang ^{[1
]}

Huang, Lin ^{[1
]}

Liu, Ke ^{[1
]}

Chen, Cheng ^{[3
]}

Wu, Qiongyou ^{[2
]}

机构：

[1] Hubei Univ Arts & Sci, Dept Chem Engn & Food Sci, Xiangyang 441053, Peoples R China

[2] Cent China Normal Univ, Coll Chem, Key Lab Pesticide Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China

[3] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Hubei, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 06期

基金：

中国国家自然科学基金;

关键词：

antimycin A; inhibitor; biological activity; structural modification; 1ST TOTAL-SYNTHESIS; ELECTRON-TRANSPORT; POTENT INHIBITORS; ANTIBIOTICS; CHEMISTRY; ANALOGS; COMPLEX; BINDING; COMPONENTS; SEPARATION;

D O I：

10.6023/cjoc201702010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Antimycin A is a class of natural products bearing a dilactone-ring moiety as the core skeleton. These compounds have been identified as specific inhibitors of the mitochondrial respiratory chain and bind to the Q(i) site of the cytochrome bc(1) complex. Due to its unique structure and extremly high activity, it has aroused great interest of researchers. The development and biological activities of antimycin A are mainly described, and the recent results of its structural modifications are summarized.

引用

页码：1368 / 1381

页数：14

共 50 条

[1] Synthesis and anticancer activity of polyhydroxylated 18-membered analogue of antimycin A3
Arsianti, Ade
Tanimoto, Hiroki
Morimoto, Tsumoru
Bahtiar, Anton
Takeya, Tatsuo
Kakiuchi, Kiyomi
[J]. TETRAHEDRON, 2012, 68 (13) : 2884 - 2891
[2] Synthesis and biological activity of 2-hydroxynicotinoyl-serine-butyl esters related to antibiotic UK-3A
Arsianti, Ade
Hanafi, Muhammad
Saepudin, Endang
Morimoto, Tsumoru
Kakiuchi, Kiyomi
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (14) : 4018 - 4020
[3] Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp.
Barrow, CJ
Oleynek, JJ
Marinelli, V
Sun, HH
Kaplita, P
Sedlock, DM
Gillum, AM
Chadwick, CC
Cooper, R
[J]. JOURNAL OF ANTIBIOTICS, 1997, 50 (09) : 729 - 733
[4] An Organotrifluoroborate-Based Convergent Total Synthesis of the Potent Cancer Cell Growth Inhibitory Depsipeptides Kitastatin and Respirantin
Beveridge, Ramsay E.
Batey, Robert A.
[J]. ORGANIC LETTERS, 2014, 16 (09) : 2322 - 2325
[5] Potent inhibitors of the Qi site of the mitochondrial respiration complex III
Bolgunas, Stephen
Clark, David A.
Hanna, Wayne S.
Mauvais, Patricia A.
Pember, Steve O.
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (15) : 4762 - 4766
[6] A new fungicide produced by a Streptomyces sp GAAS7310
Chen, GY
Lin, BR
Lin, YC
Xie, FC
Lu, W
Fong, WF
[J]. JOURNAL OF ANTIBIOTICS, 2005, 58 (08) : 519 - 522
[7] [崔树娜 Cui Shuna], 2015, [中国药理学与毒理学杂志, Chinese Journal of Pharmacology and Toxicology], V29, P573
[8] TOXICITY OF ANTIMYCIN TO FISH
DERSE, PH
STRONG, FM
[J]. NATURE, 1963, 200 (490) : 600 - &
[9] CHEMISTRY OF ANTIMYCIN A .11. N-SUBSTITUTED 3-FORMAMIDOSALICYLIC AMIDES
DICKIE, JP
FARLEY, TM
LOOMANS, ME
STRONG, FM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1963, 6 (04) : 424 - &
[10] THE ISOLATION AND PROPERTIES OF ANTIMYCIN-A
DUNSHEE, BR
LEBEN, C
KEITT, GW
STRONG, FM
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1949, 71 (07) : 2436 - 2437

← 1 2 3 4 5 →