2,4-Diphenyl-1,2-dihydroquinazoline Derivatives: Synthesis, Anticancer Activity and Docking Studies

A straightforward, rapid and efficient one-pot method was developed for the synthesis of 2,4 -diphenyl-1,2 dihydroquinazoline and their analogues. The reactions were performed with different type of benzylamine and 2-bromo benzophenone using ammonium acetate and characterized by H-1 NMR, C-13 NMR and Mass spectroscopic techniques. All the compounds were tested for MDA-MB-231, A549 and DU-145 type of human cancer cell lines. Among the synthesized compounds, 4 j (4-phenyl-2-(3,4,5-trimethoxyphenyl)-1,2-dihydroquinazoline) and 4 e (2-(3,4-dichlorophenyl)-4-phenyl-1,2-dihydroquinazoline) molecules were found to possess good anticancer activity. The binding nature of these molecules was explored through docking studies.