2,4-Diphenyl-1,2-dihydroquinazoline Derivatives: Synthesis, Anticancer Activity and Docking Studies

被引：4

作者：

Gudimella, Krishna Kanthi ^{[1
,2
]}

Bonige, Kishore Babu ^{[1
]}

Gundla, Rambabu ^{[2
]}

Katari, Naresh Kumar ^{[2
]}

Yamajala, Bhaskar ^{[2
]}

Battula, Venkateswara Rao ^{[1
]}

机构：

[1] Andhra Univ, Coll Engn, Dept Engn Chem, Visakhapatnam 530003, Andhra Pradesh, India

[2] GITAM Deemed Be Univ, Sch Sci, Dept Chem, Hyderabad 502329, India

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 43期

关键词：

Anticancer activity; Catalyst free; Dihydroquinazoline; Docking studies; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; QUINAZOLINE; INHIBITORS; DESIGN; DISCOVERY; LIGAND;

D O I：

10.1002/slct.201902609

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A straightforward, rapid and efficient one-pot method was developed for the synthesis of 2,4 -diphenyl-1,2 dihydroquinazoline and their analogues. The reactions were performed with different type of benzylamine and 2-bromo benzophenone using ammonium acetate and characterized by H-1 NMR, C-13 NMR and Mass spectroscopic techniques. All the compounds were tested for MDA-MB-231, A549 and DU-145 type of human cancer cell lines. Among the synthesized compounds, 4 j (4-phenyl-2-(3,4,5-trimethoxyphenyl)-1,2-dihydroquinazoline) and 4 e (2-(3,4-dichlorophenyl)-4-phenyl-1,2-dihydroquinazoline) molecules were found to possess good anticancer activity. The binding nature of these molecules was explored through docking studies.

引用

页码：12528 / 12533

页数：6

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