The role of triple infection with hepatitis B virus, hepatitis C virus, and human immunodeficiency virus (HIV) type-1 on CD4+ lymphocyte levels in the highly HIV infected population of North-Central Nigeria

被引:34
作者
Forbi, J. C. [1 ]
Gabadi, S. [1 ]
Alabi, R. [1 ]
Iperepolu, H. O. [1 ]
Pam, C. R. [1 ]
Entonu, P. E. [1 ]
Agwale, S. M. [1 ]
机构
[1] GRA, Innovat Biotech, Virol Lab, Keffi, Nasarawa State, Nigeria
来源
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2007年 / 102卷 / 04期
关键词
human immunodeficiency virus; hepatitis B and C viruses; Nigeria;
D O I
10.1590/S0074-02762007005000025
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
We set out to determine the seroprevalence of hepatitis B and C among human immunodeficiency virus type-1 (HIV-1) infected individuals in North-Central Nigeria to define the influence of these infections on CD4(+) lymphocytes cells among our patients as access to antiretroviral therapy improves across the Nigerian nation. The CD4(+) values of 180 confirmed HIV-1 infected individuals were enumerated using a superior fluorescence-activated cell sorter system. These patients were tested for the presence of hepatitis B surface antigen and antihepatitis C virus (HCV) using third generation enzyme-linked immunosorbent assays. Fifty (27.8%) patients had active hepatitis B virus (HBV) infection while 33 (18.3%) tested positive for anti-HCV antibody. Of these infections, 110 (61.1%), 37 (20.6%), and 20 (11.1%) had HIV only, HBV/HIV-only, and HCV/HIV-only respectively. A HBV/HCV/HIV coinfection prevalence of 7.2% (13 patients) was recorded. Patients coinfected with HIV/HBV/HCV appeared to have lower CD4(+) counts (mean = 107 cells/mu l; AIDS defining) when compared to HBV/HIV-only (mean = 377 cells/mu l), HCV/HIV-only (mean = 373 cells/mu l) and patients with mono HIV infection (mean = 478 cells/mu l). Coinfection with HBV or HCV is relatively common among HIV-infected patients in Nigeria and should be a big consideration in the initiation and choice of therapy.
引用
收藏
页码:535 / 537
页数:3
相关论文
共 14 条
[1]   Prevalence of HCV coinfection in HIV-infected individuals in Nigeria and characterization of HCV genotypes [J].
Agwale, SM ;
Tanimoto, L ;
Womack, C ;
Odama, L ;
Leung, K ;
Duey, D ;
Negedu-Momoh, R ;
Audu, I ;
Mohammed, SB ;
Inyang, U ;
Graham, B ;
Ziermann, R .
JOURNAL OF CLINICAL VIROLOGY, 2004, 31 :S3-S6
[2]   Immune recovery is associated with persistent rise in hepatitis C virus RNA, infrequent liver test flares, and is not impaired by hepatitis C virus in co-infected subjects [J].
Chung, RT ;
Evans, SR ;
Yang, YJ ;
Theodore, D ;
Valdez, H ;
Clark, R ;
Shikuma, C ;
Nevin, T ;
Sherman, KE .
AIDS, 2002, 16 (14) :1915-1923
[3]  
Feld JJ, 2005, ANTIVIR THER, V10, P953
[4]   Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study [J].
Greub, G ;
Ledergerber, B ;
Battegay, M ;
Grob, P ;
Perrin, L ;
Furrer, H ;
Burgisser, P ;
Erb, P ;
Boggian, K ;
Piffaretti, JC ;
Hirschel, B ;
Janin, P ;
Francioli, P ;
Flepp, M ;
Telenti, A .
LANCET, 2000, 356 (9244) :1800-1805
[5]   Seroprevalence of hepatitis C virus among blood donors in Rivers State, Nigeria [J].
Koate, BBD ;
Buseri, FI ;
Jeremiah, ZA .
TRANSFUSION MEDICINE, 2005, 15 (05) :449-451
[6]   Hepatitis C virus infection - Related morbidity and mortality among patients with human immunodeficiency virus infection [J].
Monga, HK ;
Rodriguez-Barradas, MC ;
Breaux, K ;
Khattak, K ;
Troisi, CL ;
Velez, M ;
Yoffe, B .
CLINICAL INFECTIOUS DISEASES, 2001, 33 (02) :240-247
[7]  
Odemuyiwa SO, 2001, J MED VIROL, V65, P463, DOI 10.1002/jmv.2058
[8]   Antiretroviral treatment change among HIV, hepatitis B virus and hepatitis C virus co-infected patients in the Australian HIV Observational Database [J].
Petoumenos, K ;
Ringland, C .
HIV MEDICINE, 2005, 6 (03) :155-163
[9]   Hepatitis C viremia persistently suppressed by HAART [J].
Ranieri, R ;
Santambrogio, C ;
Veronelli, A ;
Pontiroli, AE .
CLINICAL INFECTIOUS DISEASES, 2003, 36 (08) :1086-1087
[10]   Current HIV treatment guidelines - An overview [J].
Rathbun, RC ;
Lockhart, SM ;
Stephens, JR .
CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (09) :1045-1063