Oral mucositis: Current knowledge and future directions

被引：28

作者：

Shetty, Sameep S. ^{[1
]}

Maruthi, Meghana ^{[2
]}

Dhara, Vasantha

Almeida de Arruda, Jose Alcides ^{[3
]}

Guimaraes, Lucas ^{[4
]}

Mesquita, Ricardo Alves ^{[5
]}

Teixeira, Antonio Lucio ^{[6
,7
]}

Silva, Tarcilia Aparecida ^{[8
]}

Merchant, Yash

机构：

[1] Manipal Acad Higher Educ, Manipal Coll Dent Sci, Dept Oral & Maxillofacial Surg, Manipal 576104, India

[2] HealthCare Global Enterprises Ltd, Dept Dent Rehabil Oncol, Bangalore, Karnataka, India

[3] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg Pathol & Clin Dent, Av Pres Antonio Carlos 6627,Room 3202 D, BR-31270910 Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Sch Dent, Dept Childs & Adolescents Oral Hlth, Belo Horizonte, MG, Brazil

[5] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg Pathol & Clin Dent, Belo Horizonte, MG, Brazil

[6] Fac Santa Casa BH, Belo Horizonte, MG, Brazil

[7] Univ Texas Hlth Sci Ctr Houston, Neuropsychiat Program, Dept Psychiat & Behav Sci, Houston, TX 77030 USA

[8] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg Pathol & Clin Dent, Av Pres Antonio Carlos 6627,Room 3204, BR-31270910 Belo Horizonte, MG, Brazil

来源：

DM DISEASE-A-MONTH | 2022年 / 68卷 / 05期

关键词：

Chemotherapy; Differential diagnosis; Head and neck cancer radiation; Management; Oral mucositis; Oral oncology; Salivary glands; LEVEL LASER THERAPY; NECK-CANCER; RADIATION-THERAPY; DOUBLE-BLIND; WEIGHT-LOSS; RADIOTHERAPY; HEAD; MANAGEMENT; CHEMOTHERAPY; METAANALYSIS;

D O I：

10.1016/j.disamonth.2021.101300

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Oral mucositis secondary to head and neck chemoradiation displays a complex molecular pathogenesis involving epithelial and microvascular injury, release of pro-inflammatory cytokines, and host-microbiome communications. These processes lead to oxidative stress and the release of reactive oxygen species that stifle the structural integrity of the oral mucosa, with emergence of erosions and ulcers. The consequences are malnutrition, psychological/psychiatric symptoms, poor quality of life, and occurrence of opportunistic infections. The latter pose a major challenge due to the risk of interruption of anti-neoplastic therapy, tumour recurrence and, ultimately, death. This article aims to present the clinical characteristics, molecular pathogenesis, and an overview of the predisposing factors and current management of oral mucositis. It is anticipated that the future direction of the management of oral mucositis will focus on evidence based prehabilitation and pre-and per-chemoradiation therapy monitoring. (c) 2021 Elsevier Inc. All rights reserved.

引用

页数：21

共 98 条

[1] Use of oral mucosal neutrophil counts to detect the onset and resolution of profound neutropenia following high-dose myelosuppressive chemotherapy [J].