Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes

被引：43

作者：

Sharma, Basista Rabina ^{[1
]}

Jaiswal, Swarna ^{[2
,3
]}

Ravindra, P., V ^{[1
]}

机构：

[1] CSIR Cent Food Technol Res Inst CFTRI, Dept Biochem, KRS Rd, Mysuru 570020, India

[2] Technol Univ Dublin, Coll Sci & Hlth, Sch Food Sci & Environm Hlth, City Campus, Dublin D07 ADY7, Ireland

[3] Technol Univ Dublin, Environm Sustainabil & Hlth Inst, City Campus, Dublin D07 H6K8, Ireland

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 152卷

关键词：

Type; 2; diabetes; Gut microbiota; Eubiosis; Dysbiosis; CHAIN FATTY-ACIDS; RED WINE POLYPHENOLS; DIET-INDUCED OBESITY; INTESTINAL MICROBIOTA; INSULIN-RESISTANCE; AKKERMANSIA-MUCINIPHILA; INFLAMMATION; METABOLITES; CONSUMPTION; MICROFLORA;

D O I：

10.1016/j.biopha.2022.113148

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM.

引用

页数：11

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