Application of Three-dimensional (3D) Tumor Cell Culture Systems and Mechanism of Drug Resistance

被引：25

作者：

Shehzad, Adeeb ^{[1
]}

Ravinayagam, Vijaya ^{[2
,3
]}

AlRumaih, Hamad ^{[4
]}

Aljafary, Meneerah ^{[5
]}

AlMuhazay, Dana ^{[6
]}

Almofty, Sara ^{[6
]}

Al-Rashid, Noor A. ^{[1
]}

Al-Suhaimi, Ebtesam ^{[5
,6
]}

机构：

[1] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, Dammam, Saudi Arabia

[2] Sci Res, Dammam, Saudi Arabia

[3] Imam Abdulrahman Bin Faisal Univ, Dammam, Saudi Arabia

[4] Imam Abdulrahman Bin Faisal Univ, Coll Dent, Dammam, Saudi Arabia

[5] Imam Abdulrahman Bin Faisal Univ, Coll Sci, Dept Biol, Dammam, Saudi Arabia

[6] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Stem Cell Res Dept, Dammam, Saudi Arabia

来源：

CURRENT PHARMACEUTICAL DESIGN | 2019年 / 25卷 / 34期

关键词：

Spheroid; 3D cell culture; drug resistance; drug discovery; cancer therapy; 2D monolayer; IN-VITRO; MULTICELLULAR SPHEROIDS; STROMAL CELLS; CANCER; CURCUMIN; MODEL; DISCOVERY; ENRICHMENT; GROWTH; PHARMACOKINETICS;

D O I：

10.2174/1381612825666191014163923

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The in-vitro experimental model for the development of cancer therapeutics has always been challenging. Recently, the scientific revolution has improved cell culturing techniques by applying three dimensional (3D) culture system, which provides a similar physiologically relevant in-vivo model for studying various diseases including cancer. In particular, cancer cells exhibiting in-vivo behavior in a model of 3D cell culture is a more accurate cell culture model to test the effectiveness of anticancer drugs or characterization of cancer cells in comparison with two dimensional (2D) monolayer. This study underpins various factors that cause resistance to anti-cancer drugs in forms of spheroids in 3D in-vitro cell culture and also outlines key challenges and possible solutions for the future development of these systems.

引用

页码：3599 / 3607

页数：9

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