Enantioselective SERS sensing of pseudoephedrine in blood plasma biomatrix by hierarchical mesoporous Au films coated with a homochiral MOF

被引:49
作者
Guselnikova, Olga [1 ,2 ]
Lim, Hyunsoo [3 ,4 ]
Na, Jongbeom [3 ]
Eguchi, Miharu [3 ,5 ,6 ]
Kim, Hyun-Jong [7 ]
Elashnikov, Roman [1 ]
Postnikov, Pavel [1 ,2 ]
Svorcik, Vaclav [1 ]
Semyonov, Oleg [2 ]
Miliutina, Elena [1 ,2 ]
Lyutakov, Oleksiy [1 ,2 ]
Yamauchi, Yusuke [3 ,5 ,6 ]
机构
[1] Univ Chem & Technol, Dept Solid State Engn, Prague 16628, Czech Republic
[2] Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Tomsk 634049, Russia
[3] Univ Queensland, Australian Inst Bioengn & Nanotechnol AIBN, Brisbane, Qld 4072, Australia
[4] Korea Elect Technol Inst KETI, New & Renewable Energy Res Ctr, 25 Saenari Ro, Seongnam Si 13509, Gyeonggi Do, South Korea
[5] Natl Inst Mat Sci NIMS, JST ERATO Yamauchi Mat Space Tecton Project, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan
[6] Natl Inst Mat Sci NIMS, Int Ctr Mat Nanoarchitecton WPI MANA, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan
[7] Korea Inst Ind Technol KITECH, Surface Technol Grp, Incheon 21999, South Korea
关键词
Mesoporous gold; Homochiral MOF; SERS; Pseudoephedrine; Biosensor; Blood plasma; ENHANCED RAMAN-SCATTERING; METAL-ORGANIC FRAMEWORKS; LIQUID-CHROMATOGRAPHY; GOLD NANOPARTICLES; SPECTROMETRY; CHEMISTRY; EPHEDRINE; COLUMN; DRUGS; AG;
D O I
10.1016/j.bios.2021.113109
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Here, we present a new family of hierarchical porous hybrid materials as an innovative tool for ultrasensitive and selective sensing of enantiomeric drugs in complex biosamples via chiral surface-enhanced Raman spectroscopy (SERS). Hierarchical porous hybrid films were prepared by the combination of mesoporous plasmonic Au films and microporous homochiral metal-organic frameworks (HMOFs). The proposed hierarchical porous substrates enable extremely low limit of detection values (10-12 M) for pseudoephedrine in undiluted blood plasma due to dual enhancement mechanisms (physical enhancement by the mesoporous Au nanostructures and chemical enhancement by HMOF), chemical recognition by HMOF, and a discriminant function for bio-samples containing large biomolecules, such as blood components. We demonstrate the effect of each component (mesoporous Au and microporous AlaZnCl (HMOF)) on the analytical performance for sensing. The growth of AlaZnCl leads to an increase in the SERS signal (by around 17 times), while the use of mesoporous Au leads to an increase in the signal (by up to 40%). In the presence of a complex biomatrix (blood serum or plasma), the hybrid hierarchical porous substrate provides control over the transport of the molecules inside the pores and prevents blood protein infiltration, provoking competition with existing plasmonic materials at the limit of detection and enantioselectivity in the presence of a multicomponent biomatrix.
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页数:11
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