Synthesis and antimitotic activity of novel 5-aminoisoxazoles bearing alkoxyaryl moieties

被引：20

作者：

Vasilenko, Dmitry A. ^{[1
]}

Averina, Elena B. ^{[1
,2
]}

Zefirov, Nikolay A. ^{[1
]}

Wobith, Birgit ^{[3
]}

Grishin, Yuri K. ^{[1
]}

Rybakov, Victor B. ^{[1
]}

Zefirova, Olga N. ^{[1
,2
]}

Kuznetsova, Tamara S. ^{[1
]}

Kuznetsov, Sergei A. ^{[3
]}

Zefirov, Nikolay S. ^{[1
,2
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

[2] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka 142432, Russia

[3] Univ Rostock, Inst Biol Sci Cell Biol & Biosyst Technol, D-18059 Rostock, Germany

来源：

MENDELEEV COMMUNICATIONS | 2017年 / 27卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

ELECTROPHILIC ALKENES; COMMON PHARMACOPHORE; COLCHICINE SITE; DRUG DESIGN; ANALOGS; HETEROCYCLIZATION; TETRANITROMETHANE; DERIVATIVES; INHIBITORS; ALCOHOLS;

D O I：

10.1016/j.mencom.2017.05.003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

5-Aminoisoxazoles containing trimethoxy- and methylenedioxyphenyl moieties were prepared by heterocyclization of electrophilic alkenes with tetranitromethane in the presence of triethylamine with subsequent reduction of resulting 5-nitroisoxazoles. The crystal structure of 3,4,5-trimethoxybenzyl 5-aminoisoxazole-3-carboxylate was determined by X-ray analysis. Two novel 5-aminoisoxazoles demonstrated moderate antimitotic activity to human lung carcinoma A549 cell line.

引用

页码：228 / 230

页数：3

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