Genomic evidence for complementary purine metabolism in the pea aphid, Acyrthosiphon pisum, and its symbiotic bacterium Buchnera aphidicola

被引：41

作者：

Ramsey, J. S. ^{[1
,2
]}

MacDonald, S. J. ^{[3
]}

Jander, G. ^{[2
]}

Nakabachi, A. ^{[4
]}

Thomas, G. H. ^{[3
]}

Douglas, A. E. ^{[1
]}

机构：

[1] Cornell Univ, Dept Entomol, Ithaca, NY 14853 USA

[2] Boyce Thompson Inst Plant Res, Ithaca, NY 14853 USA

[3] Univ York, Dept Biol, York YO10 5YW, N Yorkshire, England

[4] RIKEN, Adv Sci Inst, Wako, Saitama 3510198, Japan

来源：

INSECT MOLECULAR BIOLOGY | 2010年 / 19卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Acyrthosiphon pisum; Buchnera aphidicola; insect; nucleotide synthesis; purine salvage; pea aphid; symbiosis; POLYAMINE COMPOSITION; NITROGEN; EXCRETION; INSECT; PHOSPHORIBOSYLTRANSFERASE; EXPRESSION; STRESS; ACID; GENE;

D O I：

10.1111/j.1365-2583.2009.00945.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purine salvage pathway recycles purines to nucleotides, promoting efficient utilization of purine nucleotides. Exceptionally among animals with completely sequenced genomes, the pea aphid lacks key purine recycling genes that code for purine nucleoside phosphorylase and adenosine deaminase, indicating that the aphid can neither metabolize nucleosides to the corresponding purines, nor adenosine to inosine. Purine metabolism genes in the symbiotic bacterium Buchnera complement aphid genes, and Buchnera can meet its nucleotide requirement from aphid-derived guanosine. Buchnera demand for nucleosides may have relaxed the selection for purine recycling in the aphid, leading to the loss of key aphid purine salvage genes. Further, the coupled purine metabolism of aphid and Buchnera could contribute to the dependence of the pea aphid on this symbiosis.

引用

页码：241 / 248

页数：8

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