The Biology of Aging and Cancer Frailty, Inflammation, and Immunity

被引：95
|
作者：
Zhang, Xinwen [1 ]
Meng, Xin [2 ]
Chen, Yiyin [4 ]
Leng, Sean X. [4 ]
Zhang, Haiyan [3 ]
机构：
[1] China Med Univ, Dept Prosthodont, Shenyang, Liaoning, Peoples R China
[2] China Med Univ, Dept Biochem & Mol Biol, Shenyang, Liaoning, Peoples R China
[3] China Med Univ, Dept Geriatr, Shenyang, Liaoning, Peoples R China
[4] Johns Hopkins Univ, Sch Med, Div Geriatr Med & Gerontol, Baltimore, MD USA
来源：
CANCER JOURNAL | 2017年 / 23卷 / 04期
关键词：
Aging; cancer; frailty; geriatrics; immunity; immunosenescence; inflammation; OLDER WOMEN; T-CELLS; SERUM INTERLEUKIN-6; GERIATRIC SYNDROME; PREVALENT FRAILTY; CYTOMEGALOVIRUS; EXPRESSION; INFECTION; MORTALITY; MONOCYTES;
D O I：
10.1097/PPO.0000000000000270
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The majority of patients with common malignancies are older adults. Intrinsic complex biological changes of aging along with inflammation, immunosenescence, age-associated chronic diseases, and extrinsic environmental and psychosocial factors have significant impact on not only development and behavior of individualmalignancies, but also physiologic reserve and vulnerability of older patients who suffer from them. As a result, clinical practice of geriatric oncology demands integration of careful geriatric assessment and management. This article provides an overview of basic biology of aging and its relationship with cancer. After a brief introduction about the definition and mechanisms of aging, as well as age-related biological and physiological changes, the discussionmainly focuses on recent development and insights into the relationship of frailty, inflammation, and immunity with cancer, highlighting how the new knowledge can help further improve assessment and treatment of older patients with malignancies and promote cancer research.
引用
收藏
页码：201 / 205
页数：5
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