The genetic architecture of psychophysiological phenotypes

被引：20

作者：

Munafo, Marcus R. ^{[1
,2
,3
,4
]}

Flint, Jonathan ^{[1
,2
,3
,4
]}

机构：

[1] Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol BS8 1TU, Avon, England

[2] Univ Bristol, UK Ctr Tobacco & Alcohol Studies, Bristol BS8 1TU, Avon, England

[3] Univ Bristol, Sch Expt Psychol, Bristol BS8 1TU, Avon, England

[4] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

来源：

PSYCHOPHYSIOLOGY | 2014年 / 51卷 / 12期

基金：

英国医学研究理事会; 英国经济与社会研究理事会;

关键词：

Genetics; Genetic architecture; Intermediate phenotypes; Genome-wide association study; GENOME-WIDE; ASSOCIATION; SMOKING; SCHIZOPHRENIA; ABNORMALITIES; HERITABILITY; VARIANTS; COTININE; CLUSTER; CNVS;

D O I：

10.1111/psyp.12355

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

It is now clear that almost all complex traits have a highly polygenic component; that is, their genetic basis consists of relatively frequent risk alleles at a very large number of loci, each making a small contribution to variation, or disease susceptibility. This general conclusion appears to hold for intermediate phenotypes. Therefore, we should not expect these phenotypes to be associated with substantially larger effect sizes than conventional phenotypes. Instead, their usefulness is likely to lie in understanding the mechanism underpinning associations identified via genome-wide association studies of conventional phenotypes.

引用

页码：1331 / 1332

页数：2

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