Bone metabolism in rheumatoid arthritis

被引：0

作者：

Jacobs, JWG

de Nijs, RNJ

Lems, WF

Bijlsma, JWJ

机构：

[1] Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, NL-3508 GA Utrecht, Netherlands

[2] Free Univ Amsterdam Hosp, Dept Rheumatol, Amsterdam, Netherlands

来源：

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2000年 / 18卷 / 05期

关键词：

bone metabolism; bone; bone formation; osteoblasts; bone resorption; bone loss; osteoclasts; bone markers; hypogonadism; androgens; cytokines; bone histomorphometry; osteoporosis; osteopenia; rheumatoid arthritis;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In active RA, bone resorption is increased and bone formation is normal or reduced in comparison to healthy controls. This uncoupling of bone formation and resorption with a negative remodelling balance lends to generalized bone loss. The pathogenesis of this altered bone metabolism is multifactorial, involving non-disease-specific factors (such as age, female sex and postmenopausal status) and disease-specific factors. Disease-specific factors are associated with disease activity (inflammatory cells and cytokines; hypogonadism), disease outcome (especially reduced mobility), and disease medication (e.g. corticosteroids).

引用

页码：S5 / S11

页数：7