Utility of plasma tumour necrosis factor-α and transforming growth factor-β1 as predictors of survival and treatment outcome in advanced non-small cell lung carcinoma

被引：9
作者：
Kumar, Sachin [1 ]
Guleria, Randeep [1 ]
Mohan, Anant [1 ]
Singh, Vikas [1 ]
Ali, Ashraf [1 ]
Bharti, Alok C. [2 ]
Das, Bhudev C. [3 ]
机构：
[1] All India Inst Med Sci, Dept Med, New Delhi 110029, India
[2] Inst Cytol & Prevent Oncol, Div Mol Oncol, Noida, Uttar Pradesh, India
[3] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi 110007, India
来源：
BIOMARKERS | 2010年 / 15卷 / 05期
关键词：
Chemotherapy; diagnosis; prognosis; response; GROWTH-FACTOR; TNF-ALPHA; SERUM-LEVELS; CANCER-TREATMENT; PHASE-II; LINES; CYTOKINES; INTERFERON; EXPRESSION; THERAPY;
D O I：
10.3109/1354750X.2010.485699
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We hypothesized that plasma level of tumour necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta 1 may be a potential tool for diagnosis, prognosis and prediction of treatment outcome in non-small cell lung carcinoma (NSCLC). Plasma levels of TNF-alpha and TGF-beta 1 were quantified in 100 NSCLC patients and 100 controls. Association of TNF-alpha and TGF-beta 1 with response to therapy and survival was determined in 42 patients. An increased presence of TNF-alpha and TGF-beta 1 was observed in NSCLC compared with controls. TNF-alpha and TGF-beta 1 levels did not correlate with survival and response to chemotherapy. TNF-alpha and TGF-beta 1 do not appear to be reliable markers for predicting survival and response to therapy in advanced NSCLC.
引用
收藏
页码：446 / 453
页数：8
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