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Utility of plasma tumour necrosis factor-α and transforming growth factor-β1 as predictors of survival and treatment outcome in advanced non-small cell lung carcinoma
被引:9
作者:
Kumar, Sachin
[1
]
Guleria, Randeep
[1
]
Mohan, Anant
[1
]
Singh, Vikas
[1
]
Ali, Ashraf
[1
]
Bharti, Alok C.
[2
]
Das, Bhudev C.
[3
]
机构:
[1] All India Inst Med Sci, Dept Med, New Delhi 110029, India
[2] Inst Cytol & Prevent Oncol, Div Mol Oncol, Noida, Uttar Pradesh, India
[3] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi 110007, India
来源:
关键词:
Chemotherapy;
diagnosis;
prognosis;
response;
GROWTH-FACTOR;
TNF-ALPHA;
SERUM-LEVELS;
CANCER-TREATMENT;
PHASE-II;
LINES;
CYTOKINES;
INTERFERON;
EXPRESSION;
THERAPY;
D O I:
10.3109/1354750X.2010.485699
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
We hypothesized that plasma level of tumour necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta 1 may be a potential tool for diagnosis, prognosis and prediction of treatment outcome in non-small cell lung carcinoma (NSCLC). Plasma levels of TNF-alpha and TGF-beta 1 were quantified in 100 NSCLC patients and 100 controls. Association of TNF-alpha and TGF-beta 1 with response to therapy and survival was determined in 42 patients. An increased presence of TNF-alpha and TGF-beta 1 was observed in NSCLC compared with controls. TNF-alpha and TGF-beta 1 levels did not correlate with survival and response to chemotherapy. TNF-alpha and TGF-beta 1 do not appear to be reliable markers for predicting survival and response to therapy in advanced NSCLC.
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页码:446 / 453
页数:8
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