Utility of plasma tumour necrosis factor-α and transforming growth factor-β1 as predictors of survival and treatment outcome in advanced non-small cell lung carcinoma

被引:9
作者
Kumar, Sachin [1 ]
Guleria, Randeep [1 ]
Mohan, Anant [1 ]
Singh, Vikas [1 ]
Ali, Ashraf [1 ]
Bharti, Alok C. [2 ]
Das, Bhudev C. [3 ]
机构
[1] All India Inst Med Sci, Dept Med, New Delhi 110029, India
[2] Inst Cytol & Prevent Oncol, Div Mol Oncol, Noida, Uttar Pradesh, India
[3] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi 110007, India
关键词
Chemotherapy; diagnosis; prognosis; response; GROWTH-FACTOR; TNF-ALPHA; SERUM-LEVELS; CANCER-TREATMENT; PHASE-II; LINES; CYTOKINES; INTERFERON; EXPRESSION; THERAPY;
D O I
10.3109/1354750X.2010.485699
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
We hypothesized that plasma level of tumour necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta 1 may be a potential tool for diagnosis, prognosis and prediction of treatment outcome in non-small cell lung carcinoma (NSCLC). Plasma levels of TNF-alpha and TGF-beta 1 were quantified in 100 NSCLC patients and 100 controls. Association of TNF-alpha and TGF-beta 1 with response to therapy and survival was determined in 42 patients. An increased presence of TNF-alpha and TGF-beta 1 was observed in NSCLC compared with controls. TNF-alpha and TGF-beta 1 levels did not correlate with survival and response to chemotherapy. TNF-alpha and TGF-beta 1 do not appear to be reliable markers for predicting survival and response to therapy in advanced NSCLC.
引用
收藏
页码:446 / 453
页数:8
相关论文
共 50 条
  • [21] In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-α and transforming growth factor-β genes
    Leiro, JM
    Alvarez, E
    Arranz, JA
    Siso, IG
    Orallo, F
    BIOCHEMICAL PHARMACOLOGY, 2003, 65 (08) : 1361 - 1371
  • [22] Influence of transforming growth factor-β1 and tumor necrosis factor-α genes polymorphisms on the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis C patients
    Radwan, Mohamed I.
    Pasha, Heba F.
    Mohamed, Rasha H.
    Hussien, Hala I. M.
    El-Khshab, Mohamed N.
    CYTOKINE, 2012, 60 (01) : 271 - 276
  • [23] Transforming growth factor-β1 suppresses the up-regulation of matrix metalloproteinase-2 by lung fibroblasts in response to tumor necrosis factor-α
    Ye, Hong
    Cai, Peng-Cheng
    Zhou, Qiong
    Ma, Wan-Li
    WOUND REPAIR AND REGENERATION, 2011, 19 (03) : 392 - 399
  • [24] Association of interleukin-10, tumor necrosis factor-α and transforming growth factor-β gene polymorphisms with the outcome of diffuse large B-cell lymphomas
    Tarabar, Olivera
    Cikota-Aleksic, Bojana
    Tukic, Ljiljana
    Milanovic, Nenad
    Aleksic, Aleksandar
    Magic, Zvonko
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2014, 19 (01) : 186 - 192
  • [25] The role of epidermal growth advanced non-small cell lung factor receptor in carcinoma
    Jänne, PA
    ANNALS OF MEDICINE, 2003, 35 (07) : 450 - 457
  • [26] Transforming growth factor-β1 in regulatory T cell biology
    Moreau, Joshua M.
    Velegraki, Maria
    Bolyard, Chelsea
    Rosenblum, Michael D.
    Li, Zihai
    SCIENCE IMMUNOLOGY, 2022, 7 (69)
  • [27] Growth inhibition induced by transforming growth factor-β1 in human oral squamous cell carcinoma
    Wang, Xiumei
    Sun, Wenjing
    Bai, Jing
    Ma, Linlin
    Yu, Yang
    Geng, Jingshu
    Qi, Jiping
    Shi, Zhongcheng
    Fu, Songbin
    MOLECULAR BIOLOGY REPORTS, 2009, 36 (05) : 861 - 869
  • [28] Interferon-γ, tumor necrosis factor-α, and transforming growth factor-β inhibit cyclic AMP-induced Schwann cell differentiation
    Lisak, RP
    Bealmear, B
    Benjamins, JA
    Skoff, AM
    GLIA, 2001, 36 (03) : 354 - 363
  • [29] Plasma transforming growth factor-β1 levels in patients with erectile dysfunction
    Ji-Kan Ryu
    Sun U.Song
    Hyung-Ki Choi
    Do-Hwan Seong
    Sang-Min Yoon
    Seong-Jin Kim
    Jun-Kyu Suh
    AsianJournalofAndrology, 2004, (04) : 349 - 353
  • [30] Plasma transforming growth factor-β1 levels in patients with erectile dysfunction
    Ryu, JK
    Song, SU
    Choi, HK
    Seong, DH
    Yoon, SM
    Kim, SJ
    Suh, JK
    ASIAN JOURNAL OF ANDROLOGY, 2004, 6 (04) : 349 - 353