Evidence on the use of platelet-rich plasma for diabetic ulcer: A systematic review

被引：95

作者：

Villela, Diana Lima ^{[1
]}

Santos, Vera Lucia C. G. ^{[2
]}

机构：

[1] AC Camargo Canc Hosp, Dept Continuing Educ, Sao Paulo, Brazil

[2] Univ Sao Paulo, Sch Nursing, EEUSP SP, Sao Paulo, Brazil

来源：

GROWTH FACTORS | 2010年 / 28卷 / 02期

关键词：

Platelet-rich plasma; wound healing; diabetic ulcer; CHRONIC NONHEALING WOUNDS; GROWTH-FACTOR; FOOT ULCERS; AMPUTATION PREVENTION; HEALING FACTORS; TRIAL; GEL; POPULATION; PROTOCOL;

D O I：

10.3109/08977190903468185

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The aim of topical wound treatment is to favor efficient, rapid, and safe healing. The platelet-rich plasma (PRP) has been used for wound treatment since it contains various platelet growth factors. The objective of the present study was to collect evidence regarding the use of PRP for the topical treatment of chronic leg ulcers. For this purpose, a systematic review of the literature was performed according to the steps recommended by the Cochrane Collaboration with studies published until July 2008. Among 18 selected studies, 7 (39%) of these studies were randomized clinical. Five of the seven randomized clinical trials studied ulcers of diabetic etiology. The results of meta-analysis showed that PRP favors the healing process (95% CI: 2.94-20.31). In conclusion, the present systematic review and meta-analysis show that there is a scientific evidence regarding favorable outcomes of the use of PRP for the treatment of diabetic ulcer.

引用

页码：111 / 116

页数：6

共 30 条

[1]

[Anonymous], 2004, GIORNALE ITALIANO DI

[2]

ATRI SC, 1990, SURGERY, V108, P508

[3]

Bernardo W M., 2004, Rev Assoc Med Bras, V50, P104

[4] Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site [J].

Bing, Ma ;

Da-Sheng, Cheng ;

Zhao-Fan, Xia ;

Dao-Feng, Ben ;

Wei, Lu ;

Zhi-Fang, Cao ;

Qiang, Wang ;

Jia, He ;

Jia-Ke, Chai ;

Chuan-An, Shen ;

Yong-Hua, Sun ;

Guo-An, Zhang ;

Xiao-Hua, Hu .

WOUND REPAIR AND REGENERATION, 2007, 15 (06) :795-799

[5] Platelet gel for healing cutaneous chronic wounds [J].

Crovetti, G ;

Martinelli, G ;

Issi, M ;

Barone, M ;

Guizzardi, M ;

Campanati, B ;

Moroni, M ;

Carabelli, A .

TRANSFUSION AND APHERESIS SCIENCE, 2004, 30 (02) :145-151

[6]

DOUCETTE MM, 1989, ARCH PHYS MED REHAB, V70, P780

[7]

Driver VR, 2006, OSTOMY WOUND MANAG, V52, P68

[8]

DVORAK HF, 1995, AM J PATHOL, V146, P1029

[9] Platelet-rich plasma preparation using three devices: Implications for platelet activation and platelet growth factor release [J].

Everts, Peter A. M. ;

Mahoney, Christine Brown ;

Hoffmann, Johannes J. M. L. ;

Schonberger, Jacques P. A. M. ;

Box, Henk A. M. ;

Van Zundert, Andre ;

Knape, Johannes T. A. .

GROWTH FACTORS, 2006, 24 (03) :165-171

[10]

Ganio C, 1993, J Foot Ankle Surg, V32, P263

← 1 2 3 →