Toll-like receptor 4 in CNS pathologies

被引：327

作者：

Buchanan, Madison M. ^{[1
,2
]}

Hutchinson, Mark ^{[3
]}

Watkins, Linda R. ^{[2
,4
]}

Yin, Hang ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[2] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA

[3] Univ Adelaide, Discipline Pharmacol, Adelaide, SA, Australia

[4] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 2010年 / 114卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

endogenous ligand; glia; MD-2; neuroinflammation; Toll-like receptor; sepsis; SIGNAL-TRANSDUCTION INHIBITOR; DORSAL-VENTRAL POLARITY; AMYLOID BETA-PEPTIDE; HEAT-SHOCK PROTEINS; ALZHEIMERS-DISEASE; INNATE IMMUNITY; GENE-PRODUCT; LIPID-RAFTS; INFLAMMATORY RESPONSES; EXPERIMENTAL STROKE;

D O I：

10.1111/j.1471-4159.2010.06736.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

P>The responses of the brain to infection, ischemia and trauma share remarkable similarities. These and other conditions of the CNS coordinate an innate immune response marked by activation of microglia, the macrophage-like cells of the nervous system. An important contributor to microglial activation is toll-like receptor 4, a pathogen-associated molecular pattern receptor known to initiate an inflammatory cascade in response to various CNS stimuli. The present review traces new efforts to characterize and control toll-like receptor 4 in inflammatory etiologies of the nervous system.

引用

页码：13 / 27

页数：15

共 120 条

[1] Migration and differentiation of neural precursor cells can be directed by microglia [J].

Aarum, J ;

Sandberg, K ;

Haeberlein, SLB ;

Persson, MAA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) :15983-15988

[2] Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains [J].

Abate, Wondwossen ;

Alghaithy, Abdulaziz A. ;

Parton, Joan ;

Jones, Kenneth P. ;

Jackson, Simon K. .

JOURNAL OF LIPID RESEARCH, 2010, 51 (02) :334-344

[3] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[4] Cell mediators of inflammation in the Alzheimer disease brain [J].

Akiyama, H ;

Arai, T ;

Kondo, H ;

Tanno, E ;

Haga, C ;

Ikeda, K .

ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2000, 14 :S47-S53

[5] ESTABLISHMENT OF DORSAL-VENTRAL POLARITY IN THE DROSOPHILA EMBRYO - THE INDUCTION OF POLARITY BY THE TOLL GENE-PRODUCT [J].

ANDERSON, KV ;

BOKLA, L ;

NUSSLEINVOLHARD, C .

CELL, 1985, 42 (03) :791-798

[6] ESTABLISHMENT OF DORSAL-VENTRAL POLARITY IN THE DROSOPHILA EMBRYO - GENETIC-STUDIES ON THE ROLE OF THE TOLL GENE-PRODUCT [J].

ANDERSON, KV ;

JURGENS, G ;

NUSSLEINVOLHARD, C .

CELL, 1985, 42 (03) :779-789

[7] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [J].

Arbour, NC ;

Lorenz, E ;

Schutte, BC ;

Zabner, J ;

Kline, JN ;

Jones, M ;

Frees, K ;

Watt, JL ;

Schwartz, DA .

NATURE GENETICS, 2000, 25 (02) :187-+

[8] Role of TLR4 polymorphisms in inflammatory responses -: Implications for unsuccessful aging [J].

Balistreri, Carmela Rita ;

Candore, Giuseppina ;

Listi, Florinda ;

Fazio, Teresa ;

Gangi, Simona ;

Incalcaterra, Egle ;

Caruso, Marco ;

Li Vecchi, Maurizio ;

Lio, Domenico ;

Caruso, Calogero .

MOLECULAR MECHANISMS AND MODELS OF AGING, 2007, 1119 :203-207

[9] TLR4 Polymorphisms and Ageing: Implications for the Pathophysiology of Age-Related Diseases [J].

Balistreri, Carmela Rita ;

Colonna-Romano, Giuseppina ;

Lio, Domenico ;

Candore, Giuseppina ;

Caruso, Calogero .

JOURNAL OF CLINICAL IMMUNOLOGY, 2009, 29 (04) :406-415

[10] Involvement of TLR4/type IIL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes [J].

Blanco, AM ;

Vallés, SL ;

Pascual, M ;

Guerri, C .

JOURNAL OF IMMUNOLOGY, 2005, 175 (10) :6893-6899

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