Fixed dose 4-factor prothrombin complex concentrate for bleeding caused by long acting anticoagulant rodenticides

被引：4

作者：

Doyle, Richard J. ^{[1
]}

Elfessi, Zane ^{[1
,2
]}

Kolman, Kevin ^{[1
]}

机构：

[1] Jesse Brown Vet Affairs Med Ctr, Dept Emergency Med, 820 S Damen Ave, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Pharm, Dept Pharm Practice, 833 S Wood St, Chicago, IL 60612 USA

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 2018年 / 36卷 / 10期

关键词：

Rodenticides; Brodifacoum; Difenacoum; Prothrombin complex concentrates; INTRACRANIAL HEMORRHAGE; URGENT REVERSAL; BRODIFACOUM; INGESTION; WARFARIN; SAFETY;

D O I：

10.1016/j.ajem.2018.06.040

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Acute, unintentional drug-related poisonings lead to an estimated 418,313 ED visits in 2014, according to the latest statistics from the Center for Disease Control and Prevention. While most of these were opiate-related poisonings, anticoagulant rodenticides were the most common cause of rodenticide-related poisoning in the United States. Many clinical syndromes and treatment algorithms have been described for patients with anticoagulant rodenticide poisoning. We report a case of an acute ingestion of two anticoagulant rodenticides and successful reversal of coagulation parameters using 4-factor prothrombin complex concentrate in a fixed-dose approach. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：1922.e3 / 1922.e4

页数：2

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