Internal distribution of micro-/nano-sized ceramics and metals particles in mice

被引：5

作者：

Abe, Shigeaki ^{[1
]}

Kida, Ikuhiro ^{[1
]}

Esaki, Mitsue ^{[1
,2
]}

Iwadera, Nobuki ^{[1
]}

Mutoh, Mami ^{[3
]}

Koyama, Chika ^{[3
]}

Akasaka, Tsukasa ^{[1
]}

Uo, Motohiro ^{[1
]}

Kuboki, Yoshinori ^{[1
]}

Morita, Manabu ^{[2
]}

Sato, Yoshinori ^{[4
]}

Haneda, Koichi ^{[5
]}

Yonezawa, Tetsu ^{[6
]}

Jeyadevan, Balachandran ^{[4
]}

Tohji, Kazuyuki ^{[4
]}

Watari, Fumio ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Dent Med, Kita Ku, Sapporo, Hokkaido 0608586, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral Hlth, Okayama 7008525, Japan

[3] Hokkaido Univ, Sch Dent Med, Kita Ku, Sapporo, Hokkaido 0608586, Japan

[4] Tohoku Univ, Grad Sch Environm Studies, Aoba Ku, Sendai, Miyagi 9808579, Japan

[5] Ishinomaki Senshu Univ, Dept Informat Technol & Elect, Ishinomaki, Miyagi 9868580, Japan

[6] Hokkaido Univ, Div Mat Sci & Engn, Grad Sch Engn, Kita Ku, Sapporo, Hokkaido 0608628, Japan

来源：

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN | 2010年 / 118卷 / 1378期

关键词：

Biodistribution; Micro-/nano-sized particles; Metal oxides; Chemical species; Magnetic resonance imaging; Time-dependence; MAGNETIC PARTICLES; CARBON NANOTUBES; BIODISTRIBUTION; TOXICITY;

D O I：

10.2109/jcersj2.118.525

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Internal distribution of several nanoparticles in mice has been investigated using scanning X-ray analytical microscopy, magnetic resonance imaging and inductively coupled plasma atomic emission spectroscopy. According dynamic laser scattering analysis, the actual particle size of obtained metal oxide was similar to that of metal particles. The estimated diameters were ca. one micrometer. After administration through the tail vein of the mice, metal particles quickly reached some organs. The distribution ratio reached a constant value and was then maintained. On the other hand, the metal oxide particles were first localized in the spleen and lung. The concentration in the lung was decreased with post-injection time. This result suggested that the particles were temporally trapped in the lung then removed to other organs. The behaviors between metal and metal oxide were quite different even when those particles had a similar actual particle size. Therefore, the distribution behavior of particles depended on the chemical species. (C) 2010 The Ceramic Society of Japan All rights reserved.

引用

页码：525 / 529

页数：5

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