Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on

被引：6

作者：

ZHAO, Yinjuan ^{[1
]}

CHENG, Qi ^{[2
]}

SHEN, Zizhu ^{[1
]}

FAN, Ben ^{[1
]}

XU, Yan ^{[1
]}

CAO, Yuting ^{[1
]}

PENG, Fanxi ^{[1
]}

ZHAO, Jingkai ^{[1
]}

XUE, Bin ^{[2
,3
]}

机构：

[1] Nanjing Forestry Univ, Inst Forest Protect, Collaborat Innovat Ctr Sustainable Forestry South, Coll Forestry, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Sir Run Run Hosp, Core Lab, Nanjing, Jiangsu, Peoples R China

[3] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China

来源：

FOOD SCIENCE AND TECHNOLOGY | 2021年 / 41卷

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

natural products; prodigiosin; Serratia marcescens (S; marcescens) NJZT-1; anticancer activity; LAMTSC2-null cells; BIOSYNTHESIS; LYMPHANGIOLEIOMYOMATOSIS; CELLS; GENE; MUTATIONS; APOPTOSIS; SURVIVIN; TSC2;

D O I：

10.1590/fst.35719

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Prodigiosin, a secondary metabolite extracted from Serratia marcescens (S. marcescens), could induce apoptosis in various cancer cells, with however low toxicity on normal cells. The red pigment was extracted from a strain S. marcescens NJZT-1 isolated from soil, which had antibacterial activity. Spectral analyses (LC-ESI-MS, UV-VIS spectrophotometry, infrared spectra and HPLC) and TLC indicated the presence of prodigiosin in the extracellular bacterial culture extracts. The red pigment effectively killed the TSC2-null cells, whose mutation resulted in the progressive and systemic disease LAM. Our findings provide interesting evidence and important basis for the development of new therapeutic compounds with high potential effects against TSC2-null cells.

引用

页码：189 / 196

页数：8

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