Endogenous microRNA sponges: evidence and controversy
被引:1681
作者:
Thomson, Daniel W.
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机构:
Garvan Inst Med Res, 384 Victoria St, Darlinghurst, NSW 2010, Australia
UNSW Australia, St Vincents Clin Sch, Kensington, NSW 2052, AustraliaGarvan Inst Med Res, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Thomson, Daniel W.
[1
,2
]
Dinger, Marcel E.
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机构:
Garvan Inst Med Res, 384 Victoria St, Darlinghurst, NSW 2010, Australia
UNSW Australia, St Vincents Clin Sch, Kensington, NSW 2052, AustraliaGarvan Inst Med Res, 384 Victoria St, Darlinghurst, NSW 2010, Australia
Dinger, Marcel E.
[1
,2
]
机构:
[1] Garvan Inst Med Res, 384 Victoria St, Darlinghurst, NSW 2010, Australia
[2] UNSW Australia, St Vincents Clin Sch, Kensington, NSW 2052, Australia
The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with shared microRNA (miRNA) binding sites compete for post-transcriptional control. This hypothesis has gained substantial attention as a unifying function for long non-coding RNAs, pseudogene transcripts and circular RNAs, as well as an alternative function for messenger RNAs. Empirical evidence supporting the hypothesis is accumulating but not without attracting scepticism. Recent studies that model transcriptome-wide binding-site abundance suggest that physiological changes in expression of most individual transcripts will not compromise miRNA activity. In this Review, we critically evaluate the evidence for and against the ceRNA hypothesis to assess the impact of endogenous miRNA-sponge interactions.
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Ala, Ugo
Karreth, Florian A.
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机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Karreth, Florian A.
Bosia, Carla
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h-index: 0
机构:
Human Genet Fdn, I-10126 Turin, ItalyHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Bosia, Carla
Pagnani, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Human Genet Fdn, I-10126 Turin, Italy
Politecn Torino, Dept Appl Sci & Technol, I-10129 Turin, Italy
Politecn Torino, Ctr Computat Studies, I-10129 Turin, ItalyHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Pagnani, Andrea
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Taulli, Riccardo
Leopold, Valentine
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h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Leopold, Valentine
Tay, Yvonne
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h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Tay, Yvonne
Provero, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Turin, Ctr Mol Biotechnol, I-10124 Turin, Italy
Univ Turin, Dept Mol Biotechnol & Hlth Sci, I-10124 Turin, ItalyHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Provero, Paolo
Zecchina, Riccardo
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h-index: 0
机构:
Human Genet Fdn, I-10126 Turin, Italy
Politecn Torino, Dept Appl Sci & Technol, I-10129 Turin, Italy
Politecn Torino, Ctr Computat Studies, I-10129 Turin, ItalyHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Arvey, Aaron
Larsson, Erik
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机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Larsson, Erik
Sander, Chris
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Sander, Chris
Leslie, Christina S.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Leslie, Christina S.
Marks, Debora S.
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
Baek, Daehyun
Villen, Judit
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
Villen, Judit
Shin, Chanseok
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h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
Shin, Chanseok
Camargo, Fernando D.
论文数: 0引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
Camargo, Fernando D.
Gygi, Steven P.
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
Gygi, Steven P.
Bartel, David P.
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h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
机构:
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA
Whitehead Inst Biomed Res, Cambridge, MA 02142 USAMIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Betel, Doron
Koppal, Anjali
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机构:
Columbia Univ, Dept Comp Sci, New York, NY 10027 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Koppal, Anjali
Agius, Phaedra
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机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Agius, Phaedra
Sander, Chris
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机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Sander, Chris
Leslie, Christina
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Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
机构:
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Bosson, Andrew D.
Zamudio, Jesse R.
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MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Zamudio, Jesse R.
Sharp, Phillip A.
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机构:
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Ala, Ugo
Karreth, Florian A.
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h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Karreth, Florian A.
Bosia, Carla
论文数: 0引用数: 0
h-index: 0
机构:
Human Genet Fdn, I-10126 Turin, ItalyHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Bosia, Carla
Pagnani, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Human Genet Fdn, I-10126 Turin, Italy
Politecn Torino, Dept Appl Sci & Technol, I-10129 Turin, Italy
Politecn Torino, Ctr Computat Studies, I-10129 Turin, ItalyHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Pagnani, Andrea
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机构:
Taulli, Riccardo
Leopold, Valentine
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Leopold, Valentine
Tay, Yvonne
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h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USAHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Tay, Yvonne
Provero, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Turin, Ctr Mol Biotechnol, I-10124 Turin, Italy
Univ Turin, Dept Mol Biotechnol & Hlth Sci, I-10124 Turin, ItalyHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
Provero, Paolo
Zecchina, Riccardo
论文数: 0引用数: 0
h-index: 0
机构:
Human Genet Fdn, I-10126 Turin, Italy
Politecn Torino, Dept Appl Sci & Technol, I-10129 Turin, Italy
Politecn Torino, Ctr Computat Studies, I-10129 Turin, ItalyHarvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Canc Genet Program, Beth Israel Deaconess Canc Ctr,Dept Pathol & Med, Boston, MA 02215 USA
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Arvey, Aaron
Larsson, Erik
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Larsson, Erik
Sander, Chris
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Sander, Chris
Leslie, Christina S.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Leslie, Christina S.
Marks, Debora S.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
Baek, Daehyun
Villen, Judit
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
Villen, Judit
Shin, Chanseok
论文数: 0引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
Shin, Chanseok
Camargo, Fernando D.
论文数: 0引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
Camargo, Fernando D.
Gygi, Steven P.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
Gygi, Steven P.
Bartel, David P.
论文数: 0引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAHarvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
机构:
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA
Whitehead Inst Biomed Res, Cambridge, MA 02142 USAMIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Betel, Doron
Koppal, Anjali
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Comp Sci, New York, NY 10027 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Koppal, Anjali
Agius, Phaedra
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Agius, Phaedra
Sander, Chris
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
Sander, Chris
Leslie, Christina
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA
机构:
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Bosson, Andrew D.
Zamudio, Jesse R.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Zamudio, Jesse R.
Sharp, Phillip A.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAMIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA