Endogenous microRNA sponges: evidence and controversy

被引:1681
作者
Thomson, Daniel W. [1 ,2 ]
Dinger, Marcel E. [1 ,2 ]
机构
[1] Garvan Inst Med Res, 384 Victoria St, Darlinghurst, NSW 2010, Australia
[2] UNSW Australia, St Vincents Clin Sch, Kensington, NSW 2052, Australia
关键词
LONG-NONCODING-RNA; MESSENGER-RNAS; CIRCULAR RNAS; COMPUTATIONAL PREDICTION; EXPERIMENTAL VALIDATION; WIDE IDENTIFICATION; CERNA HYPOTHESIS; TUMOR-SUPPRESSOR; BINDING PROTEIN; 3'UTR FUNCTIONS;
D O I
10.1038/nrg.2016.20
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with shared microRNA (miRNA) binding sites compete for post-transcriptional control. This hypothesis has gained substantial attention as a unifying function for long non-coding RNAs, pseudogene transcripts and circular RNAs, as well as an alternative function for messenger RNAs. Empirical evidence supporting the hypothesis is accumulating but not without attracting scepticism. Recent studies that model transcriptome-wide binding-site abundance suggest that physiological changes in expression of most individual transcripts will not compromise miRNA activity. In this Review, we critically evaluate the evidence for and against the ceRNA hypothesis to assess the impact of endogenous miRNA-sponge interactions.
引用
收藏
页码:272 / 283
页数:12
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