Ellagic acid mitigates sodium arsenite-induced renal and hepatic toxicity in male Wistar rats

被引：58

作者：

Mehrzadi, Saeed ^{[1
]}

Fatemi, Iman ^{[2
,3
]}

Malayeri, Ali Reza ^{[4
]}

Khodadadi, Ali ^{[5
,6
]}

Mohammadi, Fatemeh ^{[7
]}

Mansouri, Esrafil ^{[8
]}

Rashno, Mohammad ^{[5
,6
]}

Goudarzi, Mehdi ^{[4
,9
]}

机构：

[1] Iran Univ Med Sci, Razi Drug Res Ctr, Tehran, Iran

[2] Rafsanjan Univ Med Sci, Dept Physiol & Pharmacol, Rafsanjan, Iran

[3] Rafsanjan Univ Med Sci, Physiol Pharmacol Res Ctr, Rafsanjan, Iran

[4] Ahvaz Jundishapur Univ Med Sci, Med Plant Res Ctr, Ahvaz, Iran

[5] Ahvaz Jundishapur Univ Med Sci, Canc Environm & Petr Pollutants Res Ctr, Ahvaz, Iran

[6] Ahvaz Jundishapur Univ Med Sci, Fac Med, Dept Immunol, Ahvaz, Iran

[7] Univ Tehran Med Sci, Brain & Spinal Cord Injury Res Ctr, Neurosci Inst, Tehran, Iran

[8] Ahvaz Jundishapur Univ Med Sci, Fac Med, Cellular & Mol Res Ctr, Dept Anat Sci, Ahvaz, Iran

[9] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz, Iran

来源：

PHARMACOLOGICAL REPORTS | 2018年 / 70卷 / 04期

关键词：

Sodium arsenite; Oxidative stress; Ellagic acid; INDUCED OXIDATIVE DAMAGE; GENTAMICIN-INDUCED NEPHROTOXICITY; NITRIC-OXIDE; KAPPA-B; STRESS; LIVER; PROTECTS; EXPOSURE; TISSUE; METABOLISM;

D O I：

10.1016/j.pharep.2018.02.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: The aim of this study was to investigate the effect of ellagic acid (EA) on arsenic-induced renal and hepatic toxicity in rats. Methods: A total number of 35 male Wistar rats were randomly divided into five experimental groups. Group 1 received normal saline (po). Group 2 received sodium arsenite (SA, 10 mg/kg, po) for 21 days. Group 3 received EA (30 mg/kg, po) for 14 days. Groups 4 and 5 received SA 7 days prior to EA (10 and 30 mg/kg respectively) treatment and continued up to 21 days simultaneous with SA administration. Various biochemical, histological and molecular biomarkers were measured in kidney and liver. Results: Treatment with EA (more potently at dose of 30 mg/kg) restored the SA-induced alterations in serum creatinine (Cr) and blood urine nitrogen (BUN) levels as well as the changes in aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) concentrations (all p <0.001). Elevated levels of malondialdehyde (MDA) and nitric oxide (NO) in renal and hepatic tissue was reduced by EA treatment (all p <0.001). Treatment with EA enhanced the glutathione (GSH) content in liver (p < 0.001) and up-regulated renal and hepatic superoxide dismutase (SOD) and glutathione peroxidase (GPx) mRNA expression (all p <0.001). The SA-induced histopathological alterations in kidney and liver were reduced by EA treatment. Conclusion: In conclusion, the presence of EA with SA alleviated its toxic effects and EA treatment might be an effective strategy for the management of arsenic-induced renal and hepatic damage. (C) 2018 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：712 / 719

页数：8

共 41 条

[1] N-acetylcysteine and meso-2,3-dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats [J].